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《The Chinese Journal of Dermatovenereology》 2010-08
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Change of Peripheral Blood Lymphocyte Subpopulation and Levels of IL-15,IL-21 and IgE in Serum of Urticaria

LI Run-xiang,ZHU Hui-lan,LIANG Bi-hua,GONG Ye-qing,XIAO Chang-qing,LI Jia-yan,LI Yang-qi,ZHANG Xi-bao( Guangzhou Institute of Dermatology and Venerology,Guangzhou 510095,China)  
Objective To study the subpopulation of the T,B,NK lymphocyte in periperal blood and levels of IL(Interleukin)-15,IL-21 and IgE in serum of urticaria.Methods Subpopulation of the T,B,NK lymphocyte and serum levels of IL-15,IL-21 and IgE in the patients with acute urticaria(AU) and chronic urticaria(CU) were assayed by flow cytometry and ELISA.Sex and age were matched with controls Moreover,the symptom scores and course of urticaria were assessed.Results The percentage of NK cells and the ratio of CD4+/CD8+ were increased,while the percentage of CD8+ decreased in CU patients compared to controls(P0.05).But no significant changes of T,B and NK lymphocyte were found in AU patients.IL-15 and IL-21 signifi cantly decreased in AU and CU patients,but IgE increased.Weak negative correlations were demonstrated between the percentage of CD3+,CD8+ T cells and scores of symptoms in CU patients(r=-0.23,-0.25,P0.05).Significant correlations were found between the percentage of B cells and scores of symptoms as well as course in CU patients (r=0.49,0.65,P0.01).Moreover,a significant correlation was found between serum level of IL-21 and IgE (r=-0.42,P0.01) in CU patients.But no significant correlations were found in AU patients.Conclusions Our findings confirmed the concept that dysregulation of both humoral immunity and cellular immunity in urticaria was mainly related to the decreased serum levels of IL-15 and IL-21,which may induce expression of IgE produced by B cells.
【Fund】: 广州市卫生科技项目基金(2008-YB-228);; 广州市科技支撑项目(09A73150260)
【CateGory Index】: R758.24
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