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Antibacterial Activities of 8 Antimicrobial Agents Against Ureaplasma Urealyticum and Mycoplasma Hominis In vitro.

Yu Minjun,Wu Yimou,Yin Weiguo,et al.Department of Microbilogy Hengyang Medical college,Hengyang,421001  
Objective In order to instrust rational application of antibiotics clinically.Methods Antibacterial activities of 8 antimicrobial agents against 20 strains of Ureaplasma Urealyticum (UU),20 strains of Mycoplasma hominis (MH) were determined using the broth dilution.Results Jasamycin was highly active against UU and MH for UU MIC 50 was 0.25mg/L and MIC 90 2mg/L,and for MH MIC 50 was 0.125mg/L and MIC 90 0.5mg/L,Doxycycline was active against UU(MIC 50 to MIC 90 ,4 to 32mg/L),whereas the MIC 50 to MIC 90 for MH was 2 to 4mg/L.Ofloxacin was active against UU,MIC 90 for MH was 2 to 4mg/L.ofloxacin was active against UU,MIC 50 8mg/L and MIC 90 16mg/L against MH,MIC 50 2mg/L and MIC 90 4mg/L.MH was higly resistant to roxithromycin and azithromycin(MIC 50 64mg/L and MIC 90 128mg/L).Five strains of UU and 4 strains of MH ware higly resistant to tetracycline (MIC 50 64 and 32mg/L,MIC 90 128 and 64mg/L)and yet still resistant to doxycycline and minocycline (MIC 90 16 to 32mg/L),but sensitive to ofloxacin (MIC 90 4mg/L).Conclusion The results suggested that resistant determination of MH important significance to clinical drug treatment.
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