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《Chinese Journal of Pathophysiology》 1992-02
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Clearance and detoxification of endotoxin by lung

Wang Le-Feng, Huang Shan-Sheng, et al Department of Pathophysiology, Medical College of Hebei, Shi jiazhuang  
Endotoxin of in-and out-flowing pulmonary blood (IPB ,OPB) was measured by limulus chromogenic test in rabbits; Clearance of ~(51)Cr-E. coli endotoxin by lung was measured by a double indicator dilution method in rabbits; 12 and 24 hour's mortality rates was observed after E. coli endotoxin (1μg/100g b. w.) was infused through vein (ⅳ)and aorta (av)into the lead-sensitized rats. The endotoxin level of IPB (44.45±31.73 pg/ml plasma, n=13) was significantly higher than that of OPB (19.23±17.85 pg/ml plasma, n=13)in normal rabbits, (P0.01). About 50.31% of 300 μg ~(51)Cr-E. coli endotoxin was cleared when once it passed through lung (n=5). 12 hour's mortality rates of iv and ia were 16.7%(2/12) and 76.9%(10/13) respectively, (P0.01); 24 hour's mortality rates of iv and ia were 50%(6/12) and 92.3% (12/13) respectively, (P0.05). These results showed that lung cleare endotoxin from circulation blood, endotoxin is detoxified in lung.
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