Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Pathophysiology》 2000-07
Add to Favorite Get Latest Update

Changes of metallothionein contents in plasma and tissues of rabbit with atherosclerosis

LI Shu-lian, WANG Xiao-hong, XUE Lin, LIN Jing, ZHAO Chun-yu, TANG Chao-shu (Institute of Cardiovascular Research, The First Hospital, Beijing University, Beijing 100034, China) [  
AIM: To observe the level of metallothionein (MT) in liver, aorta and plasma of rabbit with atherosclerosis (AS) in order to recognize the alteration of oxidative defense system in body when AS occurred.METHODS:Preparation of AS model of rabbit induced by having high-fat diet for eight weeks; the levels of MT and malondialdehyde (MDA) were measured in the tissues of liver and aorta and plasma of rabbit.RESULTS:The MT levels in liver tissues and plasma in atherosclerotic group increased 318%( P 0 01) and 62% ( P 0 01), compared with control group, but its level in aortic tissue in atherosclerotic group decreased 33% ( P 0 01). The MDA levels in liver, aortic and plasma in atherosclerotic group increased 95%( P 0 01), 76%( P 0 01) and 42%( P 0 01), respectively, compared with control group. The changes of contents of MT in liver and plasma have relation with level of MDA in liver tissues and plasma.CONCLUSION:The alteration of MT in liver tissues and plasma in atherosclerotic rabbits may be related to lipid hyperoxidative injury.
【Fund】: 国家自然科学基金资助! (No .39730 2 2 0 )
【CateGory Index】: R364
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved