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《Chinese Journal of Pathophysiology》 2002-04
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Mechanism of exogenous nitric oxide in attenuating endotoxin-induced increase of rat pulmonary microvascular permeability

LIU Yan-mei, WANG Dian-hua,LING Yi-ling,ZHANG Jun-lan (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017,China)  
AIM and METHODS: The animal model of acute lung injury (ALI) caused by intratracheal instillation of lipopolysaccharides(LPS) in vivo and human peripheral blood polymorphonuclear neutrophil (PMN) in vitro were used to study the effects of sodium nitroprusside (SNP), nitric oxide (NO) donor, on LPS-induced PMN accumulation, microvascular permeability and PMN apoptosis. RESULTS: ① In vivo , PMN accumulation in lung, the protein content in bronchoalveolar lavage fluid (BALF) and the Evans blue dye and monastral blue dye extravasation in lung tissue of LPS group were markedly higher than those of both sham operation group and LPS+SNP group. ② In vitro, the apoptotic percentage of SNP group was much higher than that of control group, while compared with LPS group, SNP+LPS group has significantly higher apoptotic percentage. CONCLUSIONS: SNP intratracheal instillation attenuated LPS-induced microvascular permeability and alleviated ALI. PMN apoptosis induced by SNP may be one of the potential mechanisms underlying the decrease of PMN accumulation in lung tissue.
【CateGory Index】: R563.8
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Chinese Journal Full-text Database 4 Hits
1 Wang Xiaoyuan, Xia Zhongyuan, Du Daping,et al Department of Anesthesiology, Renmin Hospital, Wuhan University, Wuhan 430060, China;Role of HO-1/CO in Lipopolysaccharide-induced Acute Lung Injury and the Effect of Sodium Nitroprusside on It[J];Journal of Hubei Medical University;2005-01
2 MA Wen-pei, YANG Ying-ning, ZHOU Ding-bang, ZHOU Wen-qi (Department of Physiology, Kunming Medical College, Kunming 650031, China);The preventive effect of Panax Notoginseng saponins (PNS) on chronic hypoxic pulmonary hypertension in rats[J];Chinese Journal of Pathophysiology;2004-06
3 ZHAN Li-ying1,LI Wen-lan1,KE Wei2,XIA Zhong-yuan1 ( 1Department of Anesthesiology,Renmin Hospital,Wuhan University,Wuhan 430060,China; 2Department of Neurology, Zhongshan Hospital,Wuhan 430033,China);Relationship of p38MAPK,NF-κB and HO-1 in LPS-induced acute lung injury in rats[J];Chinese Journal of Pathophysiology;2010-09
4 XIA Zhong-yuan, WANG Xiao-yuan, DU Da-ping, et al. Department of Anesthesiology, Pepople's Hospital, Wuhan University, Wuhan 430060, China;Mechanism of protective effect of sodium nitroprusside against endotoxin- induced acute lung injury in rats[J];Chinese Journal of Anesthesiology;2006-02
Chinese Journal Full-text Database 3 Hits
1 Liu. Hong , Wu Xiongfei, Jin Xiyu . Department of Kidney, The First Affiliated Hospital, Third Military Medical University, Chongqing 400038;Effects of NO donor on the ICAM-1 expression of rats kidney after ischemic-reperfusion injury[J];Journal of Regional Anatomy and Operative Surgery;2002-01
2 LONG Xiao-ya 1, DU Li-zhong 1, HE Liang-qiang 2, LI Wen-lin 3 (? 1?Affiliated Children's Hospital of Zhejiang University, Hangzhou 310006, China; ? 2?Zhejiang Medical Academy of Science, Hangzhou 310013, China; ? 3?Jiangxi Key Lab of Medical Bio-Technology, Nanchang 330006, China);Effect of inhaled nitric oxide on adhesion molecule CD11b expression in lung neutrophils of meconium aspiration rabbits[J];Chinese Journal of Pathophysiology;2003-03
3 LONG Xiao-ya *, DU Li-zhong, YANG Ling-fei, SHEN Hong-qiang. *NICU, The Children′s Hospital of Zhejiang University School of Medicine. Hangzhou 310003, China;Effects of inhaled nitric oxide on rabbits with meconium aspiration pneumonia[J];Chinese Journal of Pediatrics;2003-08
Chinese Journal Full-text Database 3 Hits
1 YAO Lin, YU Shu-qin, ZHANG Xi-ran (College of Life Science, Nanjing Normal University, Nanjing 210097, China);Recent progresses in endotoxin-induced p38 MAPK signal transduction[J];Chinese Journal of Pathophysiology;2004-12
2 GUZhenyong ,LING Yiling,CONGBin ,etal DepartmentofPathophysiology,HebeiMedicalUniversity ,Shijiazhuang 0 5 0 0 17, China;Peroxynitrite mediated acute lung injury induced by lipopolysaccharides in rats[J];NATIONAL MEDICAL JOURNAL OF CHINA;2000-01
3 Sun Pa and Liu Wenli(Institute of Basic Medical Sciences, Beijing);Method for Measuring Pulmonary Artery Pressure by Right Cardiac Catheter in Rats[J];Acta Academiae Medicinae Sinicae;1984-06
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 WANG Ya-min,LI Qiao-ke,HU Jian-ying.Sichuan Provincial Corps Hospital CAPF,Leshan 614000,China;Clinical observation of Xueshuantong injection on chronic cardiopulmonary disease at acute exacerbation stage[J];Chinese and Foreign Medical Research;2011-11
2 LIANG Ying-qi1,JIA Xu-guang2,SHI Lu2,WU Cheng-yun3,WANG Wan-tie2(1Dean's Office,2Department of Pathophysiology,3Department of Respiratory Disease,The Second Affiliated Hospital,Wenzhou Medical College,Wenzhou 325035,China);Effect of Panax notoginoside on pulmonary arterial pressure and expression of p38 MAPK in lung tissues of hypoxic rats[J];Chinese Journal of Pathophysiology;2010-12
3 ZHAN Li-ying XIA Zhong-yuan XIA Fang CHENG Bang-chang Department of Anesthesiology,People's Hospital,Wuhan University,Wuhan 430060,China;Effect of radix paeoniae rubra on expression of p38 MAPK/iNOS/HO-1 in rats with lipopolysaccharide·induced acute lung injury[J];中华创伤杂志(英文版);2007-05
4 WU Xue-ling,ZHAO Yun-feng,WANG Xing-sheng,et al. Respiratory Institute for Respiratory Disease,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China;Effects of sodium nitroprusside (SNP) on CD14 in U937 cells induced by lipopolysaccharide[J];Chinese Journal of Critical Care Medicine;2008-11
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