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《Chinese Journal of Pathophysiology》 2002-06
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Inhibitory effect of cholecystokinin octapeptide on NF-κB activity induced by lipopolysaccharide in rat lungs

CONG Bin,LING Yi-ling,GU Zhen-yong,WANG Jun-xia, YAO Yu-xia (Department of Pathophysiology, Hebei Medical University ,Shijiazhuang 050017, China)  
AIM and METHODS: To investigate molecular mechanism of cholecystokinin octapeptide(CCK-8) protection aganist acute lung injury induced by lipopolysaccharide (LPS),effect of CCK-8 on nuclear transcription factor-kappa B(NF-κB) activity in rat lungs was measured with electrophoretic mobility shift assay(EMSA) during endotoxemia. NF-κB activity was expressed as peak areas integration of electrophoresis bands. The effect of CCK-8 on lung injury induced by LPS was observed. RESULTS: The administration of LPS to blood induced significant increase in NF-κB activity from 593 56±89 34 of control to 1 639 92±198 63( P 0 01),which was in part reversed by pretreatment of CCK-8 (823 91±97 32, P 0 01). Compared to the control, the CCK-8 pretreatment group also showed the lighter lung injury by pathological examination. CONCLUSION: CCK-8 had the inhibitory effect on NF-κB activity induced by LPS.
【Fund】: 国家自然科学基金资助 (No.395 70 30 4 )
【CateGory Index】: R363.2
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