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《Chinese Journal of Pathophysiology》 2003-01
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Reversion of the decline of cardiac function in endotoxin shock rats by cholecystokinin octapeptide

ZHAO Xiao-yun, LING Yi-ling, MENG Ai-hong, ZHANG Jun-lan (Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China)  
AIM: To verify the effect of cholecystokinin octapeptide(CCK-8) on cardiac function in endotoxin shock (ES) rats.METHODS: The rats were divided into four groups:control,lipopolysaccharide(LPS),CCK-8 and CCK-8+LPS.The left ventricle pressure(LVP),the maximal/minimum rate of LVP(±LVd p /d t max ),heart rate (HR) and mean arterial pressure (MAP) were measured.The activity of superoxide dismutase (SOD),the contents of malondialdehyde (MDA) and nitric oxide (NO) in both serum and myocardium were also measured,respectively.RESULTS: CCK-8 (40 μg·kg -1 , iv) elicited bradycardia in short time and gently increase MAP,LVP and ±LV d p /d t max . Lipopolysaccharide(LPS, 8 mg·kg -1 , iv) caused a variation in heart rate (HR)(a bradycardia following a tachycardia) and rapid decreases in MAP,LVP and ±LVd p /d t max . The rapid variation of HR and the decline of MAP,LVP and ±LVd p /d t max were reversed by pretreatment with CCK-8 in ES rats, but didn't restore to normal.The activity of SOD was increased and the contents of MDA and NO were decreased by pretreatment with CCK-8 in ES rats.CONCLUSION: The decline of cardiac function in ES rats could be reversed by pre-administration of CCK-8 and the decrease in NO production may be one of the mechanisms.
【Fund】: 河北省卫生厅重大攻关项目 (No .2K0 0 2 );; 河北省教育厅科研基金资助项目 (No.2 0 0 1 2 2 );; 河北省科技厅基金资助项目 (0 1 2 7641 0D)
【CateGory Index】: R363
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