Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Pathophysiology》 2003-01
Add to Favorite Get Latest Update

Role of glucocorticoid receptor in hepatic injury in early stage after severe multiple injury

LUO Dong-lin, ZHOU Ji-hong, LIU Bao-hua, HUANG Xian-kai, LIU Da-wei, XIONG Ren-ping, ZHANG Bo (Research Institute of Surgery, Daping Hospital, The Third Military Medical University, Chongqing 400042, China)  
AIM: To investigate the functions of GR in the course of hepatic secondary injury after severe multiple injury. METHODS: Rat model was produced by adopting severe thoracic impact injury accompanied with mono-side femur fracture, and glucocorticoid receptor was blocked before severe multiple injury. Hepatic macropathology and alterations under light microscope were examined. Maximal binding volume of glucocorticoid receptor (GR) in hepatic tissue was assayed by radio-ligand binding assay and protein content was assayed by Western blot. RESULTS: Maximal binding volume and protein content of GR were gradually decreased in hepatic tissue after severe multiple injury, obviously lower than that in normal control at 4 h after trauma ( P 0.01), and the lowest value was at 12 h after trauma. Maximal binding volume was 12.9% of normal control ( P 0.01), and protein content was 21.9% of normal control ( P 0.01). In addition, no significant pathological alteration in liver was found after trauma. However, the pathological analysis showed that the administration of GR blocker before severe multiple injury could cause severe hepatic congestion and infiltration of inflammatory cells in hepatic sinusoid in a dose-dependent manner. CONCLUSION: GR insufficiency could cause secondary hepatic injury in early stage after severe multiple injury, implying an important role of GR in injury and anti-injury mechanism of hepatic tissue cells.
【Fund】: 国家重点基础研究发展规划项目 (G1 9990 542 0 0 )
【CateGory Index】: R641
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 WU Hong-hong,GAO Ji-ling,ZHANG Jian-long,et al(Department of Nephropathy,Affiliated Traditional Chinese Medical Hospital,Xinjiang Medical University,Urumqi 83000,China);The research of hepatic configuration and function in septicemic rat[J];Journal of Xinjiang Medical University;2006-12
2 XIE Yu-gang,DENG Zhe,SUN Ji-wu (Department of Surgery of the Second People′s Hospital of Shenzhen Shenzhen,Guangdong 518035,P.R.China);Study on glucocorticoid receptor in early stage of multiple trauma[J];China Journal of Modern Medicine;2007-15
Chinese Journal Full-text Database 4 Hits
1 LIN Hai, XIAO Su-fang, LIN Zhong-qing, LIN Xue-yi, SONG Yu-na, JIANG Xi-lin (Fuzhou Military Medical College, Fuzhou 350003,China) [;The effect of glucocorticoid receptor on level of inflammatory media in rats after critical scald[J];Chinese Journal of Pathophysiology;2000-01
2 WANG Zhengguo, SUN Liying, LIU Baosong, et al. Research Institute of Surgery, Third Military Medical University, Chongqing 400042;Development of Biological Impact Machine and the Study on the Mechanism of Impact Injury[J];CHINESE JOURNAL OF TRAUMATOLOGY;1999-04
3 /MA Jun; JINBingwen; YANG xingyi; et alChinese Critical CareMedicine,;Changes of glucocorticoid receptor and cortisol in pa-tleuts with multiple system organ failure[J];CHINESE CRITICAL CARE MEDICINE;1995-06
4 Shi Hanping,Li Jianzhen,Qin Luping,et al;Change of glucocorticoid receptor in hepatic and cerebral tissues and its role in hemorrhagic rats/[J];CHINESE CRITICAL CARE MEDICINE;1996-10
Chinese Journal Full-text Database 10 Hits
1 ZHANG Zhi-tian,CHEN Shi-xiang,HUANG Jun-jie,CUI Ying(Department of Neurosurgery,Huaiyuan County Second People's Hospital,Huaiyuan 233400,China);Clinical features and treatment of severe lateral frontal orbit traffic injuries[J];Journal of Bengbu Medical College;2006-05
2 HU Song li,GE Hai yan,LUO Yun sheng,et al. (1?Department of General Surgery ,Xingqiao Hospital,the Third Military Medical University,Chongqing 400037,China; 2?Department of Internal Medicine,the People's Hospital of Shaping District,Chongqing 400030,China);Early diagnosis and treatment of duodenal injuries[J];Chongqing Medical Journal;2003-03
3 SHEN Hai ying, ZHOU Yuan guo, LU Jing li, et al. (Research Institute of Field Surgery,Daping Hospital, the Third Military Medical University, Chongqing 400042, China);The study of glucocorticoid efficiency difference between BALB/c and C57BL/6 mice[J];Chongqing Medical Journal;2003-06
4 TAN Hu 1,YANG Tian-de 1,SU Yong-ping 2,et al.(1.Department of Anesthesiology, Xinqiao Hospital, the Third Military Medical University, Chongqing 400037,China;2.State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury, College ofPreventive Medicine,the Third Military Medical University, Chongqing 400038,China;Effect of ketamine on gut original infection after radiation-burn combined injury in mice[J];Chongqing Medical Journal;2004-11
5 QU Qiang,SHI Zhong△ (Department of Emergency,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Changes of TNF-α,IL-1β and cortisol in serum and hepatic GR following severe traumatic brain injury[J];Chongqing Medicine;2007-18
6 YANG Cheng1,CHEN Ji-chuan1,WANG Yi2,et al.(1.2.Department of Otorhinolaryngology-Head and Neck Surgery,Daping Hospital,Third Military Medical University,Chongqing 400042,China;3.Department of Otorhinolaryngology,Children′ s Hospital,Chongqing University of Medical Sciences,Chongqing 400014,China);Clinical application of spiral CT three-dimensional reconstruction technique on the temporal bone impact injury[J];Chongqing Medicine;2009-09
7 FEI Mao-yun,FENG Wen-ming,BAO Ying,ZHU Ming,TAO Yu-long,WANG Yong-chun,ZHANG Xiao-lan,JIANG Xiao-ying (Department of Surgery,the First Hospital of Huzhou,Huzhou 313000,Zhejiang,China);Effects of enteral nutrition on glucocorticoid receptor and heat shock protein 70 in severe acute pancreatitis in rats[J];Parenteral & Enteral Nutrition;2007-05
8 ZHANG Ming, HE Li-sheng, BO Bin, et al . (Department of Oral & Maxillofacial Surgery, Stomatological College, Fourth Military Medical University, Xi' an 710032, China);A study on maxillofacial impact injury associated with brain injury[J];Journal of Traumatic Surgery;2001-02
9 HUANG Xian kai,YAO Yuan zhang, ZHOU Jian,et al. (Department of Traumatic Surgery ,Daping Hospital,Third Military Medical University, Chongqing 400042,China);Prevention and treatment of several kinds of early complications of serious wound[J];Journal of Traumatic Surgery;2002-03
10 HE Jia-qing,JIANG Yao-guang (Trauma Center,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Advances in the research of lung injury after chest impact injury[J];Journal of Traumatic Surgery;2005-02
Chinese Journal Full-text Database 10 Hits
1 Fan Jie, Xu Renbao (Department of Pathophysiologv .Shanghai,200433);The Development and Study of the Glucocorticoid Receptor Blockade Animal Model[J];Academic Journal of Second Military Medical University;1993-01
2 Li Min; Zhao Faji; Guo Junsheng; Li Zhengyin(Department of Public Health,Faculty of Medical Services, Second Military Medical University, Shanghai,200433);Effects of Jawei Shengmai San on the glucocorticoid and its receptor in heat-stressed rats[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1996-06
3 WANG Qing song, WANG Zheng guo, ZHU Pei fang (Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China);Establishment of PTSD model in rats and expression of glucocorticoid receptor in the hippocampi[J];Acta Academiae Medicine Militaris Tertiae;2002-02
4 WANG Jun-ping, SU Yong-ping, ZHAO Jin-hong, ZHOU Yan-hong, QIN Rong, LIU Xian-hua (Institute of Combined Injury, Third Military Medical University, Chongqing 400038, China);Effects of TNF-α and IL-1 on expression and function of glucocorticoid receptor in rat hepatocytes in vitro[J];Acta Academiae Medicine Militaris Tertiae;2002-05
5 WANG Jun ping, SU Yong ping, LIU Xian hua, ZHAO Jing hong, QIN Rong (Institute of Combined Injury, Third Military Medical University, Chongqing 400038, China);The changes and significance of the expression of HSP90α in the liver of severely scalded rats[J];Acta Academiae Medicinae Militaris Tertiae;2003-09
6 Wu Yongheng; Zhou Yiping; Fang Zhiyang(Department of Burn. Nanfang Hospital. First Military Medical University. Guangzhou, 510315;) (Institute of Burn, ChanghaiHospital. Second Military Medical University. Shanghai. 200433);Stress and immune: the relationship between lymphocyte transformation rate and the changes of plasma glucocorticoid and its receptor in dog peripheral blood lymphocyte in early stage ofburn injury[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;1999-02
7 WANG Zhi\|hong 1, XIAO Su\|fang 2, LIN Hai 2 (1.Department of Physiology, Fujian Medical University, Fuzhou 350004,China 2.Medical School of Fuzhou Millitary Region,PLA, Fuzhou 350003, China);Diminution of Glucocorticoids Receptors and Inflammatory Response Syndrome in Rats after Severe Scald[J];JOURNAL OF FUJIAN MEDICAL UNIVERSITY;2000-01
8 LUO Fei jun, XIAO Xian zhong, YOU Jia lu, WANG Yan ru, LUO Zheng yao Department of Pathophysiology, Hunan Medical University(Changsha 410078) [;The mechanism of macrophage apoptosis induced by lipopolysaccharide in mice[J];BULLETIN OF HUNAN MEDICAL UNIVERSITY;2000-05
9 Sun Yinggang, Huang Zonghai, Feng Haomiao et al. Zhujiang Hospital, First Military Medical University, Guangzhou 510282;DEVELOPMENT OF AN EXPERIMENTAL MODEL OF TRAUMATIC SHOCK IN RATS[J];Medical Journal of Chinese People's Liberation Army;2002-12
10 YIN Hui-nan, CHAI Jia-ke, YAO Yong-ming et al. Burns Institute, 304 Hospital of PLA, Beijing 100037, China;Role of NF-kappa B in pathogenesis of acute liver injury in burn rat with sepsis[J];Medical Journal of Chinese People's Liberation Army;2004-01
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Fan Jie, Xu Renbao (Department of Pathophysiologv .Shanghai,200433);The Development and Study of the Glucocorticoid Receptor Blockade Animal Model[J];Academic Journal of Second Military Medical University;1993-01
2 Liu Baosong, Wang Zhengguo, Wong Gewen, Yang Zhihuan, Li Xiaoyan (Research Institute of Field Surgery, Daping Hospital, Third Military Medical University, Chongqing, 400042);Cardiac injury and dynamic responses of the thoracic wall during thoracic impact in rabbits *[J];ACTA ACADEMIAE MEDICINE MILITARIS TERTIAE;1998-05
3 FU CHUAN-GANG;ZHONG JIAN-PING;ZHANG YA-FEI;XU REN-BAO Department of General Sergery,Changhai Hospital,Second Military Medical University,Shanghai 200433 Department of Pathophysiology, Second Military Medical University,Shanghai 200433;THE EFFECT OF TRILOSTANE AND DEXAMETHASONE ON SERUM AMINO ACIDS AND TNF IN ENDOTOXEMIC RATS[J];Acta Physiological Sinica;1993-04
4 SONG Jinliang (Department of Mechanics, Tianjin University, 300072) JIANG Yanping WANG Zhengguo LIU Baosong (The Research Institute of Surgery, the Third Military Medical University, Chongqing, 400042);Dynamic Photoelastic Stress Analysis for Human Skull Brain under Impact[J];JOURNAL OF EXPERIMENTAL MECHANICS;1998-03
5 Shi Han-Ping,Xu Ren-Bao,Gao Han, Hua Ji-De,Shen Yan-Ming Dept.of General Surgery, Nan Fang Hospital, Guangzhou( 510515);A preliminary study on the mechanism of glucocorticoid depressing IL-1 activity[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1995-05
6 YANG Zhi huan,YANG Zhi lin,WANG Zheng guo,et al. Research Institute of Surgery,Daping,Chongqing 630042 P.R.China;An Experimental Study of the Mechanisms of Neurogenic Pulmonary Edema after Brain Skull Impact[J];CHINESE JOURNAL OF TRAUMATOLOGY;1995-02
7 LIU Bao song, WANG Zheng guo, YANG Zhi huan, et al. Research Institute of Surgery, The Third Military Medical University. Chongqing 630042;The Relationship between Viscous Criterion and Lung Injuries in a Relatively Static Impact Pattern[J];CHINESE JOURNAL OF TRAUMATOLOGY;1996-03
8 NING Ke *, WANG Zheng guo, CHEN Chang cai. * Research Institute of Surgery, The Third Military Medical University . Chongqing 630042;The Effect of Nimodipine on Calcium Current of Neurons after Brain Impact Injury[J];CHINESE JOURNAL OF TRAUMATOLOGY;1996-03
9 LIN Hai *, XIAO Su fang, GONG Xiao qi, et al. * Fuzhou Military Medical College, Fuzhou 350003;Effects of Glucocorticoid Receptor Blockade on Pulmonary and Renal Function and Vascular Permeability in Scalded Rats[J];CHINESE JOURNAL OF TRAUMATOLOGY;1997-03
10 ZHU Pei fang, ZHOU Ji hong, JIN Rong bin, et al. Daping Hospital, Research Institute of Surgery, The Third Military Medical University, Chongqing 630042;Changes of Creatine Kinase Activity and Circulating Endothelial Cells after Craniocerebral Injury[J];CHINESE JOURNAL OF TRAUMATOLOGY;1997-03
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved