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《Chinese Journal of Pathophysiology》 2003-06
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Renal function damage induced by acute lung injury in aging rats

ZHANG Jian 2,DU Ye-wei 1, SUN Ren-yu 1,WANG Shi-wen 3 (? 1?Institute of Basic Medical Sciences,CAMS & PUMC, GAMS & PUMC, Beijing 100005, China; ? 2?Fuwai Hospital Cardiovascular Institute, GAMS & PUMC, Beijing 100037, China; ? 3?Institute of Gerontology and Geriatrics, General Hospital of PLA, Beijing 100856, China)  
AIM:To investigate whether renal function damage could be induced by acute lung injury(ALI)in aging rats. METHODS: 40 Wistar male rats were used for reproducing aging animal model. Aging rats were randomly divided into aging control; ALI group (Lipopolysaccharide, LPS, 5 mg/kg body weight, iv) and LPS group (same dosage LPS, intraventricle of left heart injection). The samples (blood, lung and kidney ) were collected at 2 or 6 hours after LPS or normal saline administration. RESULTS:Compared with aging control, in ALI group, creatinine (Cr) and urea nitrogen (BUN) contents in blood were increased significantly (all P 0.01) until 6 hours after LPS administration. While they were no obviously changes in LPS group. In ALI group, LD,MDA and NO - 2/NO - 3contents in blood and NO - 2/NO - 3 content in lung tissue were all increased significantly (all P 0 01) at 2,6 hours. GSH-P X,Na +-K +-ATPase activities in lung tissue were decreased significantly ( P 0 05, P 0 01) at 2,6 hours after LPS administration ( all P 0 01). Whereas in renal tissue MDA,NO - 2/NO - 3 contents were increased obviously( all P 0 01), and Na +-K +-ATPase,GSH-P X activities were decreased markedly ( P 0 01) until 6 hours after LPS administration. In LPS group, NO - 2/NO - 3content in blood at 2,6 hours and in lung tissue at 2 hours was increased (all P 0 05), as well as Na +-K +-ATPase activity in lung tissue at 2 hours was decreased( P 0 05). CONCLUSION: ALI was caused by LPS intravenous injection (5 mg/kg body weight ) in aging rats. Renal function damage could be induced by ALI in aging rats. [
【Fund】: 国家重点基础研究规划项目 (973)基金资助项目(G2 0 0 0 0 5 70 0 4 );; 国家自然科学基金资助项目 (No.30 170 4 0 0 )
【CateGory Index】: R563
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