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《Chinese Journal of Pathophysiology》 2005-04
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Relation between myocardial hypertrophy and the circulating insulin-like growth factor-1 in patients with essential hypertension

HUANG Shun-wei, GAO Xiu-ren, TANG Ke-jing (Department of Cardiology, First Affiliated Hospital, Sun Yat-sen Uni versity, Guangzhou 510080, China)  
AIM: To investigate the relationship betw ee n circulating insulin-like growth factor-1 (IGF-1) and hypertension patients wit h left ventricular hypertrophy (LVH). METHODS: Serum IGF-1 concentrations in 53 patients with essentia l hypertension and 16 healthy persons were measured by enzyme immunoassay (EIA). RESULTS: The results showed that serum IGF-1 concentration in e ssential hypertension was significantly higher than that in non-hypertension. Se rum IGF-1 concentration in myocardial hypertrophy was significantly higher than that in myocardial non-hypertrophy (275.5±116.4 vs 203.8±82.9,P0 .01). There was positive correlation between serum IGF-1 and LVMI (r=0.45) . 10 of 22 hypertension patients in pulse pressure ≤60 mmHg group were found to have myocardial hypertrophy, the ratio was 45%. Circulating IGF-1 concentration of patients with hypertension in suffering time ≥15 years is lower than that i n suffering time 15 years. 20 of 31 hypertension patients in pulse pressure 60 mmHg were found to have myocardial hypertrophy, the ratio was 65%. There was no significant difference in serum IGF-1 concentration between two groups. CONCLUSION: ①These results indicated that circulating IGF-1 con centration was increased in essential hypertension, suggesting that circulating IGF-1 participates in the pathophysiological process of essential hypertension . ②Serum IGF-1 concentration in myocardial hypertrophy was significantly higher than that in myocardial non-hypertrophy. There was positive correlation between serum IGF-1 and LVMI, indicating that serum IGF-1 may promote myocardial hypert rophy. ③According to the suffering time result, the circulating IGF-1 in hypert ens ion decreased significantly in the patients whose suffering time was less than 1 5 years. ④The hypertension patients with myocardial hypertrophy showed positive correlation with higher pulse pressure (60 mmHg), indicating that the increase in pulse pressure participates in the course of myocardial hypertrophy. ⑤There was no significant correlation between pulse pressure and serum IGF-1 concentra tion, suggesting that different mechanisms are involved in the development of my ocardial hypertrophy between pulse pressure and IGF-1.
【CateGory Index】: R541.3
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