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《Chinese Journal of Pathophysiology》 2005-11
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Effect of fluvastatin on migration of vascular smooth muscle cells from rats

HAN Ying, XIE Liang-di, XU Chang-sheng, WANG Hua-jun (Fujian Hypertension Research Institute, The First Affiliated Hospital of Fujian Medical University, Fuzhou 350005, China)  
AIM: To investigate the effect and mechanism of fluvastatin on the migration induced by platelet derived growth factor-BB (PDGF-BB) and endothelin-1 (ET-1) in cultured vascular smooth muscle cells (VSMCs). METHODS: Cultured VSMCs derived from spontaneously hypertensive rats (SHR) were used. Cell migration was determined by modified Boyden chamber assays. Intracellular free calcium ([Ca 2+ ]i) was measured with fluorescent Ca 2+ indicator Fura-2/AM. RESULTS: PDGF-BB and ET-1 significantly induced VSMCs migration, which was inhibited by pretreatment of VSMCs with fluvastatin (10 -9 -10 -5 mol/L) in a dose-dependent manner, and the peak inhibition rate of migration induced by PDGF-BB and ET-1 was over 86.67%. Fluvastatin also attenuated the increase in [Ca 2+ ]i induced by PDGF-BB and ET-1, with a peak inhibition rate of 86.76% and 65.32%, respectively. CONCLUSION: PDGF-BB and ET-1 promote migration of VSMCs from SHR.Fluvastatin may have direct inhibitory effects on cell migration induced by PDGF-BB and ET-1. The increase in [Ca 2+ ]i may acts as intracellular signaling in the migration in response to PDGF-BB and ET-1 in VSMCs.
【Fund】: 福建省医学创新课题(No.C2003-CX-12)
【CateGory Index】: R965
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【References】
Chinese Journal Full-text Database 10 Hits
1 ZHU Lei1,ZHANG Yan-hong2,SHI Guang3,CHEN Jie4,LUO En-li5,HUANG Yan5(1Guangzhou University of Chinese Medicine,Guangzhou 510405,China;2First People's Hospital of Guangzhou City,Guangzhou 510180,China;3First Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510405,China;4Foshan City Hospital of Traditional Chinese Medicine,Foshan 528000,China;5Second Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510120,China);Effects of Yinaokang Capsule on NO,VEGF,PDGF-BB content in serum of rats with atherosclerotic acute cerebral ischemia[J];China Journal of Traditional Chinese Medicine and Pharmacy;2012-08
2 YU Hui-zhen1,2,XIE Liang-di1,ZHU Peng-li2,XU Chang-sheng1 1Fujian Provincial Institute of Hypertension,First Affiliated Hospital of Fujian Medical University,Fuzhou 350005,China;2Second Medical Department,Provincial Clinical College,Fujian Medical University,Fuzhou 350001,China;Effects of human tissue kallikrein gene transfer on the migration of vascular smooth muscule cells[J];Journal of Southern Medical University;2010-04
3 LIN Wei,CAO Zhi-yun,CHEN Xu-zheng,et al(Fujian Academy of Integrative Medicine,FUTCM,Fuzhou,Fujian 350108,China);Effect of Xuefu Zhuyu Decoction on Migration of Vascular Smooth Muscle Cells in Rats[J];Journal of Fujian University of Traditional Chinese Medicine;2009-05
4 LIN Wei 1,2, ZHAO Jin-yan 1,2, ZHENG Liang-pu 1,2, CAO Zhi-yun2, CHEN Xu-zheng2, PENG Jun 1,2* (1.Fujian Academy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou,350108,China;2.Fujian Academy of Integrated Traditional Chinese Medicine and Western Medicine,Fuzhou 350108,China);Effect of XueFuZhuYu Decoction on MMP-2 and TIMP-1 Expression of Vascular Smooth Muscle Cells from Rats[J];Lishizhen Medicine and Materia Medica Research;2011-11
5 WANG Hong-yan~1,QU Peng~1,YU Zhi-hong~2,JIANG Hua~1,ZHOU Xiao-yu~3 (~1Department of Cardiology,~2 Center Laboratory,The Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China;~3 The Center Laboratory,Zhongxin Hospital of Dalian,Dalian 116000,China);Effect of TLR4 activation on endothelium adhesion function and atorvastatin intervention[J];Chinese Journal of Pathophysiology;2006-08
6 SONG Zi-fang1, LI Wei2, ZHENG Qi-chang1, GUAN Si-ming2, SHANG Dan1, GUO Xing-jun1 (1Department of General Surgery, 2Department of Geriatrics, Union Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430022, China. );Origin of smooth muscle cells in vascular neointima from recipient bone marrow cells in rat aortic allograft[J];Chinese Journal of Pathophysiology;2007-11
7 XIE Liang-di1,CHEN Hai-feng1,2,XU Chang-sheng1(1Fujian Hypertension Research Institute,The First Affiliated Hospital,Fujian Medical University,Fuzhou 350005,China;2Fujian Provincial Hospital,Fuzhou 350001,China);Effect of sodium ferulate on heat shock protein 27 phosphorylation in vascular smooth muscle cells[J];Chinese Journal of Pathophysiology;2008-12
8 XIE Liang-di1,YU Hui-zhen1,2,ZHU Peng-li2,XU Chang-sheng1,WANG Hua-jun1,LI Ti-yuan1(1Hypertension Institution of Fujian,The First Affiliated Hospital of Fujian Medical University,2The Second Medical Department,Provincial Clinical College, Fuzhou 350001,China.);Effects of human tissue kallikerin gene delivery on proliferation and migration of vascular smooth muscle cells[J];Chinese Journal of Pathophysiology;2010-04
9 CHEN Hai-feng1,2,XIE Liang-di1,XU Chang-sheng1(1Fujian Institute of Hypertension,The First Affiliated Hospital,Fujian Medical University,Fuzhou 350005,China;2Department of Cardiology,Fujian Provincial Hospital,Fuzhou 350001,China.);Fluvastatin inhibits migration of rat vascular smooth muscle cells[J];Chinese Journal of Pathophysiology;2010-08
10 LIN Wei1,2,ZHAO Jin-yan1,2,ZHENG Liang-pu1,2,CAO Zhi-yun2,CHEN Xu-zheng2,YE Hong-zhi2(1.Fujian Academy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou 350108,China;2.Fujian Academy of Integrative Medicine,Fuzhou 350108,China);Effect of Different Concentration of XueFuZhuYu Decoctions on Proliferation,Migration and Invasion of Vascular Smooth Muscle Cells in Rats[J];Chinese Journal of Comparative Medicine;2010-05
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Shou Difei,Lu Dezhao,Wang Ping'er,et al College of Life Science,Zhejiang Chinese Medical University,Hangzhou(310053);The Mechanism of Gypenosides Regulate Cholesterol Homeostasis in Foam Cells[J];Journal of Zhejiang Chinese Medical University;2011-02
2 Yu Fengchun, Zhai Yanling, Liu Yan, et al (Department of Neurology, Beijing Tongren Hospital, Beijing 100730);Study on concentration of tissue factor and thrombomodulin in acute cerebral infarction patients[J];Beijing Medical Journal;2006-04
3 Liu xiaoqing(Beijing College of Traditional Chinese Medicine, Bejing);Effect of Radix Rhapontici seu Echinopsis in Morpholgical Changes in Atherosclerosis of Quails[J];;1989-03
4 LIU Jing1, YANG Jing2, SUN Ning-ling1, MA Ji-shun1,HU Da-yi1(1. Heart Center, 2. Department of Emergency Medicine, Peking University People’s Hospital, Beijing 100044, China);Association of microalbuminuria and von Willebrand factor with metabolic syndrome in hypertensive patients[J];Journal of Peking University(Health Sciences);2007-06
5 Song Shoujun,Zhang Ying,Wang Lin,et al (Department of Endocrinology,Affiliated Hospital of Binzhou Medical College,Binzhou 256603,China);INSULIN RESISTANCE (IR) AND CAROTID ARTERIOSCLEROSIS IN IMPAIRED GLUCOSE TOLERANCE(IGT)[J];Journal of Binzhou Medical College;2003-06
6 Zhao Xianxian, Zhu Jialin, Zhang Baoren, Hao Jiahua, Liu Yanling,Zhu Quanfang (Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, 200433);The expression of vascular endothelial growth factor in atherosclerotic plaques[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1999-09
7 YANG Peng Yuan,RUI Yao Cheng *,JIAO Ya Bin (Department of Pharmacology,School of Pharmacy,Second Military Medical University,Shanghai 200433,China);Establishment of experimental atherosclerosis model in rats[J];Academic Journal of Second Military Medical University;2003-07
8 GU Guo-jun,HUANG Zhen-xing,TAO Kai-zhong,LIU Yun,TAO Heng-yi,PENG Zhao-yun,SUN Xue-jun~*(Department of Diving Medicine,Faculty of Navy Medicine, Second Military Medical University,Shanghai 200433,China);Effect of hyperbaric oxygen on an endothelin-1-induced focal cerebral ischemic model in rats[J];Academic Journal of Second Military Medical University;2006-10
9 LIN Wei,CAO Zhi-yun,CHEN Xu-zheng,et al(Fujian Academy of Integrative Medicine,FUTCM,Fuzhou,Fujian 350108,China);Effect of Xuefu Zhuyu Decoction on Migration of Vascular Smooth Muscle Cells in Rats[J];Journal of Fujian University of Traditional Chinese Medicine;2009-05
10 Liu Jiangang, Li Zhongwen, Xu Hongmei, et al. Xiyuan Hospital, Chinese Academy of Traditional Chinese Medicine, Beijing 100091;Huatuo reconstruction pill prevents thrombosis and microcirculation disorders in experimental animals[J];GUANGDONG MEDICAL JOURNAL;2000-05
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 ZHENG Liangpu,LIN Wei,ZHAO Jinyan,et al(Key Laboratory of Geriatrics of Integrated Medicine,FUTCM,Fuzhou,Fujian 350108,China);Sero-pharmacological Studies on Xuefu Zhuyu Decotion in Promoting Proliferation of Vascular Endothelial Cells[J];Journal of Fujian University of Traditional Chinese Medicine;2011-06
2 CHU Chun,YANG Jun,WANG Shu-yan,et al(Department of Pharmaceutics,the Second Affiliated Hospital,University of South China, Hengyang,Hunan 421001,China);Effect of Irbesartan on Electrical Instability and L-type Calcium Channel Current in Failing Hearts of Rats[J];Journal of Medical Science in Central South China;2012-01
3 HU Wei1,SHANG Qian-Hui1,JIANG Qian-Feng1,WU Qing2,ZHU Rong-Wen3,and YUAN Ping1 (1.Department of Cardiology,Affiliated Hospital of Zunyi Medical College & Institute of Clinical Medicine of Zunyi Medical College;2.Department of Pharmacology,Zunyi Medical College;3.Department of Nephrology,Affiliated Hospital of Zunyi Medical College,Zunyi Guizhou 563003,China);Effects of Amlodipine and Enalapril on Aorta Remodeling in Renovascular Hypertensive Rats[J];Chinese Journal of Arteriosclerosis;2012-02
4 ZUO Qiwei Department of Cardiology People's Hospital of Leiyang,Hunan province,Leiyang 421800,China;The Influence of vascular endothelial function on Fluorine Simvastatin of Primary Hypertension Patients[J];China Foreign Medical Treatment;2012-23
5 JING Sumin;CHEN Kui;HE Fei;Department of Cardiology, The Hospital of Zhengzhou University;The First Af-filiated Hospital of Zhengzhou University;;Effect of Atorvastatin on the Endothelial Functions of Patients with Hypertension Grade 2 and Normal Lipid[J];China & Foreign Medical Treatment;2013-25
6 ZHAO Gang,YANG Guan-lin,LI Zhi-ming(Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang 110032,Liaoning,China);The Influence of Atorvastatin on the Expression of Human Vascular Endothelial Cells TLR4 Induced by LPS[J];Journal of Practical Traditional Chinese Internal Medicine;2011-04
7 LIN Wei 1,2, ZHAO Jin-yan 1,2, ZHENG Liang-pu 1,2, CAO Zhi-yun2, CHEN Xu-zheng2, PENG Jun 1,2* (1.Fujian Academy of Integrative Medicine,Fujian University of Traditional Chinese Medicine,Fuzhou,350108,China;2.Fujian Academy of Integrated Traditional Chinese Medicine and Western Medicine,Fuzhou 350108,China);Effect of XueFuZhuYu Decoction on MMP-2 and TIMP-1 Expression of Vascular Smooth Muscle Cells from Rats[J];Lishizhen Medicine and Materia Medica Research;2011-11
8 HUANG Jie,XIE Liang-di,XU Chang-sheng,WANG Hua-jun(the First Affiliated Hospital of Fujian Medical University,Fujian Hypertension Research Institute,Fuzhou 350005,China);Construction and identification of a recombinant lentiviral vector harboring RNAi targeting rat HSP27 gene[J];Chinese Pharmacological Bulletin;2009-04
9 WENG Xiao-guang,ZHAO Hua-yun,WANG Wen-hui.(Internal Medicine-Cardiovascular Department,Guangzhou University of Chinese Medicine Affiliated Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,China);Research Progress of Chinese and Western Medicine in Vascular Remodeling of Hypertension[J];Medical Recapitulate;2012-13
10 GUO Xing-jun,SONG Zi-fang,ZHENG Qi-chang,ZHANG Lei,ZUO Ke-qiang(Department of Hepatobiliary Surgery,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China);Depressant effect and mechanism of atorvastatin on the chronic rejection of aortic allograft in rats[J];Chinese Journal of Pathophysiology;2007-09
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