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《Chinese Journal of Pathophysiology》 2006-05
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Effect of diterpenoid compound 5F of Peris semipinnata L on apoptosis of human pterygium body fibroblasts in vitro

CHEN Yu-dong~1,WANG Ying-fen~2,CHEN Jian-su~1,LI Zhi-jie~1,CHEN Xiao-lin~3(~1Department of Ophthalmology,~3Department of Functional Experiments,Medical College of Jinan University,Guangzhou 510632,China;~2Departmen of Ophthalmology,Affiliated Hospital of Guangdong Medical College,Zhanjiang 524001,China)  
AIM: To observe the effect of diterpenoid compound 5F of Pteris semipinnate L on apoptosis in cultured human pterygium body fibroblasts(HPFs).METHODS: Fibroblasts collected from human pterygium body were cultured in vitro with 5F at different time point.Transmission electron microscope(TEM) was used to observe the ultrastructure changes of the HPFs.The changes of the cell cycle and apoptosis of HPFs were evaluated with flow cytometry(FCM).RESULTS: 5F at the concentration of 32 mg/L induced HPF apoptosis at various time points.CONCLUSION: 5F induces HPFs apoptosis.Apoptotic cells are evolved to necrosis with the prolongation of the time.These findings indicate that 5F has a potential clinical value.
【CateGory Index】: R285
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【References】
Chinese Journal Full-text Database 1 Hits
1 Chen Yudong,Wang Yingfen,Liang Junwen.Department of Ophthalmology,Jinan University Medical College,Guangzhou 510630,China;Regulation of 5F on proliferation of human pterygia fibroblasts and expression of Fas in vitro[J];Chinese Ophthalmic Research;2006-06
【Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Yu-dong(Department of Ophthalmology,Affiliated Hospital of Guangdong Medical College,Zhanjiang Guangdong 524001);The effect of diterpenoid compound 5F of Peris semipinnata L on the changes of the cell cycle and expressions of Ki-67 in fibroblasts of human pterygium in vitro[J];Ophthalmology In China;2002-05
【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 ZHANG Li-jian 1,LI Bao-hong 2*,DONGYE Guang-zhi 1,DENG Yi-feng 2,LIANG Nian-ci 2 (1.Center Lab. of Guangdong Medical College,Zhanjiang 524023,China;2.Key Lab. of Natural Drugs Research,Guangdong Medical College,Zhanjiang 524023,China);Preparation of inclusion compound of 5F-β-cyclodextrin with Orthogonal test[J];West China Journal of Pharmaceutical Sciences;2004-03
2 ZHANG Lijian①, LI Baohong, DONGYE Guangzhi, et al. ①Center Lab of Guangdong Medical College, Zhanjiang 524023, China;Determination of 5F in the solid dispersions prepared by PEG6000 and the extract of Peris semipinnata L[J];Qianwei Journal of Medicine;2004-03
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