Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Pathophysiology》 2009-03
Add to Favorite Get Latest Update

Ischemic postconditioning ameliorates pia mater microcirculation in rats subjected to cerebral ischemia reperfusion

YAO Shu-tong1,2,LIU Xiu-hua1,TANG Xu-ming1,SUN Sheng1,WANG Jia-fu2(1Department of Pathophysiology,Chinese PLA General Hospital,Beijing 100853,China; 2Department of Pathophysiology,Taishan Medical College,Taian 271000,China.  
AIM:To investigate the ameliorative effect of ischemic postconditioning (I-postC) on pia mater microcirculation in rats subjected to cerebral ischemia reperfusion (I/R) and its mechanisms. METHODS:Thirty-two male Wistar rats were randomly divided into sham,I/R,I-postC,and ischemic preconditioning (IPC) groups. The global cerebral I/R injury was induced by shunting carotid artery in rats. Pia mater microcirculation and cerebral microcirculatory perfusion were measured after reperfusion. The content of soluble intercellular adhesion molecule-1 (sICAM-1) in plasma was detected using enzyme linked-immunosorbent assay (ELISA). Myeloperoxidase (MPO),malondialdehyde (MDA),and superoxide dismutase (SOD) in cerebral tissue were detected. The expressions of vascular endothelial cell cadherin (VE-cadherin) and NF-κB p65 in cerebral tissue were assayed by Western blotting. RESULTS:(1) The disturbance of the blood flow in microvessel induced by I/R was improved significantly by I-postC. In addition,I-postC alleviated significantly the decrease in diameters of microvesseles,cerebral microcirculatory perfusion and cerebral VE-cadherin content induced by I/R (P0.05). (2) sICAM-1 in plasma,MPO and MDA in cerebral tissue decreased,but SOD activity in cerebral tissue increased in I-postC group,compared with those in I/R group (P0.05 or P0.01). The over-expression of NF-κB p65 induced by I/R was relieved by I-postC (P0.05). CONCLUSION:I-postC ameliorates pia mater microcirculation in rats subjected to cerebral I/R through suppressing the activation of polymorphonuclear neutrophils mediated by ICAM-1.
【Fund】: 国家自然科学基金资助项目(No.30670822);; 国家自然科学基金重大国际合作资助项目(No.30620130111)
【CateGory Index】: R743
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 7 Hits
1 QIU Qing-Yan,QIN Jian,ZHENG Wei-Ping,GAO Dian-Sa,ZHAO Qian Department of Cardiology,First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China;Effects of PI3K/Akt signaling pathway on vascular endothelial function and interventional effects of erythropoietin[J];Journal of the Fourth Military Medical University;2009-22
2 LIN Huang,DONG Yong(Department of Plastic Surgery,Anzhen Hospital,Capital University of Medical Science,Beijing 100029,China);Study of the mechanism on the ischemia postconditioning for the protection of the skin flap[J];Chinese Journal of Aesthetic Medicine;2011-03
3 Mingsan Miao;Xuexia Zhang;Ming Bai;Linan Wang;Henan University of Traditional Chinese Medicine;;Persimmon leaf flavonoid promotes brain ischemic tolerance[J];中国神经再生研究(英文版);2013-28
4 Zhao Xia,Dong Shuyun,Zhang Lianyuan North China Coal Medical college,Tangshan 063000;The Changes of Mesentery Microcirculation in Rats with Hind Limbs Ischemia-Reperfusion[J];Chinese Journal of Microcirculation;2010-01
5 YAO Shu-tong1,SANG Hui1,SHANG Zhan-ping1,TIAN Hua2,FANG Yong-qi1,YU Feng-xiu1,WANG Jia-fu1(1Department of Pathophysiology,2Institute of Atherosclerosis,Taishan Medical College,Taian 271000,China.);Ischemic postconditioning inhibits activation of nuclear factor-κB and ICAM-1 expression in lungs following intestinal ischemia reperfusion in rats[J];Chinese Journal of Pathophysiology;2010-08
6 FENG Rui1,2,LI Shu-qing2(1Department of Immunology and Rheumatology,The First Affiliated Hospital,2Department of Pathophysiology,Kunming Medical University,Kunming 650031,China.);Postconditioning modulates TLR4 expression in hippocampus of tree shrews with thrombotic cerebral ischemia[J];Chinese Journal of Pathophysiology;2011-06
7 HOU Li-jun,LI Yan,ZHU Yu-hong. Department of Neurology,The Second Affiliated Hospital of Kunming Medical College,Kunming 650101,China;The mechanism and prospect of Cerebral ischemia postconditioning[J];Chinese Journal of Cerebrovascular Diseases(Electronic Edition);2010-01
【Citations】
Chinese Journal Full-text Database 5 Hits
1 Yao Shutong, Li Yuzhen, Liu Xiuhua, et al/Department of Pathophysiology, PLA General Hospital, Beijing 100853;Effect of Ischemic Postconditioning on Mesenteric Microcirculation of Rats Subjected to Small Intestinal Ischemia/Reperfusion Injury[J];Chinese Journal of Microcirculation;2007-02
2 Guo Xiaosun,Liu Xiuhua,Zhang Zhenying,et al Department of Pathophysiology, Chinese PLA General Hospital, Beijing 100853;Ischemic Postconditioning Protects Skeletal Muscle from Ischemic Reperfusion Injury through Improving Microcirculation in Rat Hind Limbs[J];Chinese Journal of Microcirculation;2007-04
3 ZHAOKe -sen ,HUANGQiao -bing (DepartmentofPathophysiology ,FirstMilitaryMedicalUniversity ,Guangzhou 5 10 5 15 ,China);The basic mechanism of increased microvascular permeability[J];Chinese Journal of Pathophysiology;2003-04
4 HAN Mei,WEN Jin-kun,LIU Yue-ping,SONG Wei(Hebei Laboratory of Medical Biotechnology,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017,China.);Activation of NF-κB and expression of ICAM-1 and COX-2 genes in rat neointimal formation[J];Chinese Journal of Pathophysiology;2008-02
5 YAO Shu-tong,ZHAO Xiu-mei,LIU Xiu-hua.Dept.of Pathophysiology,PLA General Hospital,Beijing 100853,China;ICAM-1 Inhibition Involving Small Intestinal Protection Induced by Ischemic Postconditioning in Rats[J];Journal of Chinese Microcirculation;2008-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ZHAO Ming-yue,HUANG Yue-sheng,ZHANG Qiong,WANG Guang,RUAN Jing,LEI Ze-yuan,CHU Zhi-gang,XIANG Fei (State Key Laboratory of Trauma,Burns and Combined Injury,Institute of Burns,Southwest Hospital,Third Military Medical University,Chongqing 400038,China);Role of bradykinin B1 receptor in organic vascular permeability following severe burn[J];Acta Academiae Medicinae Militaris Tertiae;2008-04
2 LIU Shao-hui,HE Ming-feng,ZHANG Ying-jian,CHEN Jing-li,MAO Rong-jun(Foshan Hospital of Traditional Chinese Medicine,Foshan 528000,China);The effect of Shenfu injection on myocardium ultrastructure in the cardiopulmonary resuscitated New Zealand rabbits[J];Journal of Foshan University(Natural Science Edition);2011-04
3 SHEN Yan~▲,FENG Hai-song,LI Hong-hua,WU Le,LIN Lang,HE Zhan-xuan,CHEN Wei-min.~▲Department of Neurology,Zhejiang Sian International Hospital,Zhejiang 314031,China;Protective Effects of Salvianolate on Endothelial Function Injury in Diabetes Mellitus Rats[J];Neural Injury and Functional Reconstruction;2013-01
4 Feng Xiao-juan~(1*),Li Yong-xin~1,Yin Jian-hua~2,et al. (1 The Hospital of Sanhe City,Hebei Provinee,Sanhe 065200,China;2 The Hospital of Dachang County,Hebei Province,Dachang 065300,China);The Clinical Study of Cardiac Function of Acute Myocardial Infarction with Normal Coronary Arteries that Treated by Trimetazidine[J];Chinese Journal of Medicinal Guide;2010-07
5 LI Rong,ZHANG Jian,LIANG Haifeng,et al.Department of Pathophysiology, Hebei North University, Hebei, Zhangjiakou 075029;Experimental research for Honghua injection in anti-microcirculation disturbance in patients with idiopathic edema[J];Hebei Medical Journal;2006-10
6 ;Management and Outcome of 52 Patients with Acute Myocardial Infarction Complicating Acute Left Heart Failure[J];China Foreign Medical Treatment;2009-01
7 ZHU Yan-jun,LI Qiang,CHEN Bo,HUANG Xu-liang,HUANG Qiao-bing~*(Department of Pathophysiology,Southern Medical University,Guangzhou 50515,China);Role of P38 MAPK activation in glucose-induced microvascular hyperpermeability of rats[J];Basic & Clinical Medicine;2006-09
8 ZHU Su-min,LI Jian-bo,TANG Ren-kuan,LIU Yun-zhi,HUANG Wei,SONG An-lin;To identify the proteins expressed differentially in myocardium of which death of neurogenic shock by HPLC-Chip/MS[J];Laser Journal;2010-04
9 ZHANG Qing-fu1,2,JIAO Bao-hua1(1.Department of Neurosurgery,the Second Hospital of Hebei Medical University,Shijiazhuang 050017,China;2.Department of Burns and Plastic Surgery,the First Hospital of Hebei Medical University,Shijiazhuang 050031,China);Influence of expression of rat CD11b/CD18 on leukocyte adhesion in experimental transcranial high-voltage electrical burns and therapeutic effects of ulinastatin[J];Bulletin of the Academy of Military Medical Sciences;2010-02
10 LIU Ke-xuan,HUANG Wen-qi;Protective effects of preconditioning and postconditioning against the intestines I/R injury[J];China Continuing Medical Education;2010-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Gang,GAO Yu qi,LIU Fu yu (Institute of Pathophysiology,Department of High Altitude Military Medicine, Third Military Medical University,Chongqing 400038,China);Effects of acute hypoxia on the rheologic properties of leukocytes in mesentery microcirculation of rats[J];Acta Academiae Medicine Militaris Tertiae;2002-03
2 GAO Dian-sa1,QIN Jian1,LAN Li2,FENG Jing3,ZHOU Mei-fang1,LIAO Hui1,YANG Jun-qing4,ZHOU Qi-xin4,CHEN Yun-zhen1(1Department of Cardiology,First Affiliated Hospital,4College of Pharmacy,Chongqing Medical University,Chongqing 400016;2Department of Cardiology,Third People's Hospital of Mianyang,Mianyang 621000,Sichuan Province;3Center for Disease Control and Prevention of Chengdu,Chengdu 610041,China);Olmesartan medoxomil attenuates vascular endothelial dysfunction and downregulates ERK/CREB mRNA expression in rats with acute myocardial infarction[J];Acta Academiae Medicinae Militaris Tertiae;2009-14
3 ZHENG Yu, XIONG Li Ze, ZHU Zheng Hua, WANG Qiang, CHEN Shao Yang Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Study of therapeutic time window for Shenfu solution in transient focal cerebral ischemic injury in rats[J];Journal of The Fourth Military Medical University;2002-15
4 CHEN Guang-Lei, WANG Han-Min, LIU Guang-Hou, CHEN Wei, HE Li-Jie, SUN Shi-Ren, ZHANG PengDepartment of Nephrology, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China;Postconditioning animal modeling of acute kidney ischemia reperfusion in rats[J];Journal of the Fourth Military Medical University;2007-09
5 SUN Jing,DONG Hai-Long,LUAN QI,ZHAO Hui,LU Zhi-Hong,XIONG Li-Ze Department of Anesthesiology,Xijing Hospital,Fourth Military Medical University,Xi'an 710033,China;Optimal protocol of ischemic postconditioning against focal cerebral ischemia-reperfusion injury in rats[J];Journal of the Fourth Military Medical University;2007-24
6 LIU Guang-Hou1, WANG Han-Min1, LI Su-Tong1, LI Man1, ZHANG Hai2, ZHANG Peng11Department of Nephrology, Xijing Hospital, 2Research Center of Laboratory Animals, Fourth Military Medical University, Xi'an 710033, China;Effects of ischemic postconditioning and Ligustrazine on oxygen free radicals in renal ischemia reperfusion rats[J];Journal of the Fourth Military Medical University;2008-08
7 SHEN Pei-Qing1,2,,ZHENG Hong1,2,,LIU Ru-Wen1,CHEN Li-Ling1,LI Bo1,HE Bao-Li1,LI Jin-Tao1,BEN Kun-Long1,3,4,CAO Xiao-Mei1,3,4,JIAO Jian-Lin1,(1.Kunming Medical University,Kunming,Yunnan 650031,China;2.Yunnan Provincial Office for Laboratory Animal Administration,Kunming,Yunnan 650031,China;3.Kunming Kangtao Biotechnology Company Ltd,Kunming,Yunnan 650106,China;4.Kunming Institute of Zoology,the Chinese Academy of Sciences,Kunming 650223,China);Progress and prospect in research on laboratory tree shrew in China[J];Zoological Research;2011-01
8 SONG Wei-bing1,LV Yong-Hui2,LI Ya-nan1,XIAO Li-ping1,YU Xin-pei1,LIU Gang1,WANG Yuan-yuan3,ZHANG Xiao-lan3,LI Ying-fei3 1Department of Gerontology,Guangzhou General Hospital of Guangzhou Command,Guangzhou 510010,China;2Guangzhou Traditional Chinese Medical Hospital,Guangzhou 510010,China;3Institute for Digestive Diseases,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China;Changyanqing decoction produces anti-inflammatory effect by inhibiting the activation of nuclear factor-κB[J];Journal of Southern Medical University;2009-07
9 YANG Ji-ping,LIU Huai-jun,ZHANG Cong-min,et al.Department of Medical Imaging,the Second Hospital of Hebei Medical University,Shijiangzhuang 050000,P.R.China;Establishment of Rabbit Model of Cerebral Ischemia-reperfusion with MRI[J];Radiologic Practice;2007-04
10 Liu Nengbao; Zhang minhai; Liu Shaochun;Dai Xiaoli;Book R; Zhou Shunchang(Department of Histology and Embryology,Faculty of Basic MedicalSciences,Tongji Medical University,430030 Wuhan;Fachrichtung 3.1Anatomie im Fachbereich Theoretische Medizin der Unive;MORPHOMETRIC ANALYSIS OF VASOPRESSINERGIC AND OXYTOCINERGIC NEURONS IN THE SUPRAOPTIC AND PARAVENTRICULAR NUCLEI OF HYPOTHALAMUS IN TUPAIA BELANGERI CHINENSISL[J];CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY;1995-01
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 WANG Peng,Lü Jinglei,SUI Xueqin,GAO Xiang,ZHAO Renliang(Department of Neurology,The Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);ISCHEMIC POSTCONDITIONING ON EXPRESSIONS OF TLR4 AND NF-κB DURING FOCAL CEREBRAL ISCHEMIA/REPERFUSION IN RATS[J];Acta Academiae Medicinae Qingdao Universitatis;2012-03
2 LIN Huang,DONG Yong(Department of Plastic Surgery,Anzhen Hospital,Capital University of Medical Science,Beijing 100029,China);Study on the mechanism of the autophagy protection activated by the ischemia postconditioning with skin flap[J];Chinese Journal of Aesthetic Medicine;2013-02
3 WANG Peng,ZHAO Ren-liang,LV Jing-lei,et al.(Department of Neurology,the Affiliated Hospital of Qingdao University Medical College,Qingdao 266003,China);Ischemic postconditioning down-rugulate expression of TLR4 and NF-кB during cerebral ischemla/reperfusion in Rats[J];Journal of Apoplexy and Nervous Diseases;2012-06
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Tian Hecun,Xie Qun,Chen Qianfen (Department of Pathophy siology,Bengbu Medical College,Anhui);A MODEL OF CEREBRAL ISCHEMIA-REPERFUSION INJURY INDUCED BY CAROTID ARTERY SHUNT IN RATS[J];Journal of Bengbu Medical College;1993-02
2 LIU Xiuhua;PANG Yongzheng;SU Jingyi;TANG Chaoshu(Laboratory of Shock Pathophysiology,Institute of Cardiovascular Research,Beijing Medical University 100083);PRECONDITIONING PROTECTES INTESTINE FROM ISCHEMIC REPERFUSION INJURY OF RAT[J];JOURNAL OF BEIJING MEDICAL UNIVERSITY;1996-01
3 Gao Peng,Xiong Lize,Nie Huang,et al.Department of Anesthesiology,Xijing Hospital,Fourth Military Medical University,Xi’an 710032 CHINA;Protective effect of ischemic postconditioning on spinal cord ischemia-reperfusion injury in rabbits[J];The Journal of Clinical Anesthesiology;2006-04
4 ZHOU Xiuxia,WEN Jinkun,HAN Mei (Department of Biochemistry,Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017);The Change of MMP-2 Gene Expression and Collagen Turnover during Vascular Restenosis Development[J];CHINESE JOURNAL OF BIOCHEMISTRY AND MOLECULAR BIOLOGY;1999-06
5 Yao Shutong, Li Yuzhen, Liu Xiuhua, et al/Department of Pathophysiology, PLA General Hospital, Beijing 100853;Effect of Ischemic Postconditioning on Mesenteric Microcirculation of Rats Subjected to Small Intestinal Ischemia/Reperfusion Injury[J];Chinese Journal of Microcirculation;2007-02
6 Chu Weiwei,Wu Buqiang,Sha Huanchen,Wang Dianhua(Yunnan Pharmacological Laboratory of Natural Products,Kunming Medical College,Kunming 650031,China);The role of ischemic postconditioning on intestinal mucosa in rats with ischemia-reperfusion injury[J];Journal of Xi'an Jiaotong University(Medical Sciences);2007-02
7 ;香烟烟雾提取物通过活化NF-κB上调小鼠 巨噬细胞ICAM-1表达[J];Chinese Journal of Pathophysiology;2006-09
8 GAO Wei-juan,XU Shun-jiang,CONG Bin,LI Shu-jin,MA Chun-ling,XU Jin-rong,YAO Yu-xia,GU Zhen-yong(Department of Pathophysiology,Hebei Medical University,Shijiazhuang 050017,China.);Inhibitory effects of CCK-8 on NF-κB activities stimulated by LPS in rat PIMs[J];Chinese Journal of Pathophysiology;2006-10
9 WANG Xiao jun1, WANG Ai min1, GUO Qing shan1,WANG Zi ming1, TANG Shou ying2 1Department of Orthopaedics and Traumatology, Daping Hospital, Third Military Medical University, Chongqing 400042, China 2Department of Orthopaedics,251st Hospital of PLA ,Zhangjiakou ,Hebei 075000, China;Study on delayed protection of ischemia preconditioning for reperfusion injury of skeletal muscle in limbs of rabbits[J];Chinese Journal of Orthopaedic Trauma;2004-03
10 GU Da-yong,LIANG Bing,TANG Xu-dong,et al.Science Laboratory,Number 401 Hospital of PLA,Shandong Qingdao 266071,China. Clinical Experimental Institute,Chendu Army General Hospital of PLA,Sichuan Chendu 610083,China;A Research on Expression of ICAM-1 and Adhesion to PMN of PMVEC Directly-Induced by LPS[J];Journal of Chinese Microcirculation;2006-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved