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《Chinese Journal of Pathophysiology》 2011-12
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Effects of puerarin on apelin-12,angiotensin II,NO and blood pressure in renovascular hypertensive rat

HUANG Zhen-gui,ZHANG Pei,YANG Fan,DING Bo-ping(Wannan Medical College,Wuhu 241002,China)  
AIM: To investigate the effects of puerarin on blood pressure in renovascular hypertensive rats,and to measure puerarin-induced changes of apelin-12,angiotensin II(Ang II) and nitric oxide(NO),the factors related to development of hypertension.METHODS: Sixty-five male Sprague-Dawley rats were used,of which 8 rats were randomly selected as sham operation group,and the remaining were used to make two-kidney,one-clip model.The rats that met the criterion for Goldblatt hypertensive rat model were randomly allocated into 5 groups: high-,middle-and low-dose puerarin groups,captopril group,and model group.The drugs were administered for 6 weeks.Blood pressure was measured every 2 weeks.Six weeks after treatment,all rats were sacrificed under deep anesthesia.Blood and kidney samples were collected.The level of apelin-12 in serum and kidneys was detected by ELISA.The level of Ang II in plasma and kidneys was measured by radioimmunoassay.NO level in serum was examined by nitrate reductase assay.RESULTS: Puerarin had an antihypertensive effect in a dose-dependent manner.Marked decreases in the level of serum apelin-12 in high-and middle-dose puerarin groups were observed(P0.01).Puerarin at low dose did not cause obvious change in the content of apelin but still reached significant level(P0.05).As the dose of puerarin went up,the level of apelin-12 in the kidneys was gradually decreased.Puerarin at high and middle doses obviously reduced the level of AngII in plasma,while purarin at low dose did not produce any significant effects.Puerarin at high and middle doses markedly increased the level of NO in serum,but puerarin at low dose did not induce any significant changes.CONCLUSION: Puerarin has an antihypertensive effect,and its mechanism may be related to inducing the changes of apelin,Ang II and NO,and regulating the balance among those factors.
【Fund】: 安徽省自然科学基金资助项目(No.070413124);; 皖南医学院博士启动基金资助项目(No.BK00010804)
【CateGory Index】: R285.5
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