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Protective effect of radix salviae miltiorrhize on ethanol-induced gastric mucosal damage in rats and mechanism

Chang Jiang,Deng Chang-Sheng,et al Gastroenterology Department ,the Second Affiliated Hospital,Hubei Medical Uaiversity,Wuhan  
The protective effect of radix salviae miltiorrhize ( RSM) on gastric mu-cosa and its mechanism were studied by observing the effects of RSM on the ethanol-induced gastric mucosal lesions,gastric mucus, gastric emptying in rats,and its relation toindomethacin and exogenous PGE_1. The results indicated that RSM could protect gastricmucosa from absolute ethanol-indnced damage and increase gastric mucus secretion in rats.Pretreatment with indomethacin could partly abolish this effect, and intragastric abminis-tration of exogenous PGE_1 analogue could restore this effects.It was suggested theseeffects were mediated partly by the increased endogenous PGs stimulated by RSM.Amber-lit pellets were given intragastrically to quantify gastric emptying of solid s a nd the re-sults showed that RSM inhibited gastric emptying and reduced gastric mucosal folds so asto protect the gastric mucosa against ethanol-induced damage.
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