Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《CHINESE JOURNAL OF PATHOPHYSIOLOGY》 1995-05
Add to Favorite Get Latest Update

A preliminary study on the mechanism of glucocorticoid depressing IL-1 activity

Shi Han-Ping,Xu Ren-Bao,Gao Han, Hua Ji-De,Shen Yan-Ming Dept.of General Surgery, Nan Fang Hospital, Guangzhou( 510515)  
Fifty-four Sprague-Dawley male rats were equally divided into 3 groupsrandomly, and were injected intramuscularly with sesame oil(5mg/kg)and Ru_(486)(5mg/kg or 100mg/kg) as to block 0.50%,80%of GR respectivelv, Half of each groupwere shed 10%of their total blood volume 1h after treatment. It was found that 50%GR blocked and shed rats present much higher plasma IL-1 activity than that of thecontrol rats. As compared with their own baseline, IL-1 activity increased obviously(P0.01 )at 150 min and reached a peak at 180 min after Ru_(486) injection. While in80%of the GR blocked group, the shed rats showed a much higher IL-1 activity than50% GR blocked and shed rat did.The increased pattern of IL-1 activity was almostthe same. Similar result was obtained in rat with GR blocked only, although the incre-ased value of IL-1 activity seemed lower than that of the GR blocked and shed rat.Similar findings were also obtained in vitro study of Ru_(486) on IL-1.Ru_486 effectivelyblocked the inhibitive effect of corticosterone on IL-1 secretion from peritoneal macroph-ages.There exist a dose-dependent relation between Ru_(486)and IL-1 activity. Result indi-cated that either in vivo or in vitro study,on hemorrhagic or normal rats, GR mightbe an important mediator of IL-1 activity,i.e.it is GR that mediate the inhibitive ef-fect of glucocorticoid on IL-1 secretion.
【CateGory Index】: R977.11
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 -SUN Kai-hong~1,YIN Jian-chun~2,YAN Jun~3(1.P.E Department, Yangzhou Educational College, Yangzhou 225002, China;2.P.E Department, Huaiyin Normal College,Huaiyin 223002, China; 3. College of Physical Education, Yangzhou Univercity, Yangzhou 225002, China);Effect of Low and Moderate Exercise on PlasmaCorticosterone and IL-1β in Rats After Mental Stress[J];Journal of Xi'an Institute of Physical Education;2004-06
2 Shi Hanping,Li Jianzhen,Qin Luping,et al;Change of glucocorticoid receptor in hepatic and cerebral tissues and its role in hemorrhagic rats/[J];CHINESE CRITICAL CARE MEDICINE;1996-10
【Citations】
Chinese Journal Full-text Database 1 Hits
1 Wu Jian Gong Xiaoqi Zhang Yafei Xu Renbao Department of Pathophysiology The Second Military Medical University Shanghai 200433;EFFECT OF GLUCOCORTICOID RECEPTOR (GR) BLOCKED BY RU_(486) ON MESENTERIC MICROCIRCULATORY AND LEUKOCYTE MICROHEMOEHEOLOGICALY CHANGE AFTER ACUTE HEMORRHAGE IN RATS[J];Chinese Journal of Hemorheology;1992-01
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 Song Fen,Jing Liang.Department of Anesthesiology,Zhongda Hospital,Southeast University,Nanjing 210009 CHINA;Protective effect of glutamine on expression of glucocorticoid receptor in endotoxic shock rats[J];The Journal of Clinical Anesthesiology;2006-08
2 CHANG Li-guo,PENG Shou-chun,LI Yong-chun.Department of Respiratory Suizhong County Hospital of Huludao,Suizhong 125200,China;The Therapeutics Advancement of Glucocorticoid on Acute Lung Injury[J];Chinese General Practice;2006-08
3 Shi Han-ping,Xu Ren-Bao,Tan Jin-Xing,Gao Han Dept.of General Surgery,Nan Fang Hospital,Guangzhou( 510515);Study on the relation between tissue GR(glucocorticoid receptor )and plasma IL-1 in hemorrhagic rat[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1995-06
4 LU Jun-Hua, LIN Chang-Quang, TAN Jin-Xing, XU Ren-Bao Department of Pathophysiology, Second Military Medical University, Shanghai (200433);Effects of Gu Tuo Tang (GTT) on the glucocorticoid receptors in rats during hemorrhagic shock[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1998-02
5 LU Jun-hua LIN Chang-quan TAN Jin-xing Shanghai Eastern Hospital of Hepatobiliary Surgery,Shanghai(200432)Changhai Hospital,Shanghai Dept.of Pathophysiology,Second Military Medical University;Effect of Gu-Tuo Decoction(固脱汤)on Glucocorticoid Receptors in Hepatic Cytosol of Hemorrhagic Shock Rat[J];Chinese Journal of Integrated Traditional and Western Medicine;1996-S1
6 Lu Junhua Lin Changquan Wu Jian Dept.of Pathophysiology,The Second Military Medical University,Shanghai(200433) Changhai Hospital,The Second Military Medical University;Effects of Gutuo Decoction(固脱汤)on Mesenteric Microcirculatory Changes after Hemorrhagic Shock in Rats[J];Chinese Journal of Integrated Traditional and Western Medicine;1998-S1
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Yang Yili, et al (Department of Pathophysiology);DETERMINATION OF THE MOLECULAR WEIGHT OF PHOTOAFFINiTY LABELED GLUCOCORTICOSD RECEPTOR IN SCALDED RAT LIVER CYTOSOL[J];Academic Journal of Second Military Medical University;1987-04
2 Fan Jie, Xu Renbao (Department of Pathophysiologv .Shanghai,200433);The Development and Study of the Glucocorticoid Receptor Blockade Animal Model[J];Academic Journal of Second Military Medical University;1993-01
3 Ma Jun, Jing Hingwen, Yang Xingyi, Chen Xueyun,Yan Ming ' Zhao Liang (Emergency Department, Changzheng Hospital, Second Military Medical University, Shanghai, 200003);The significance of glucocorticoid receptor in treatment of acute respiratory distress syndrome[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1996-03
4 Yu Mengxue,etal;Pathogenesis of Rheumatoid Arthritis[J];BASIC MEDICAL SCIENCES AND CLINICS;1998-04
5 Gong Qinzhi; Zhu Cheng ; Yang Zhongjian ; et al. (Changzheng Hospita1 , Second Mil- litary Medical University , Shanghai 200003);THE CONCENTRATION OF DEXAMETHASONE IN PLASMA AND BRAIN TISSUE DURING THE TREATMENT OF TRAUMATIC BRAIN EDEMA[J];MEDICAL JOURNAL OF CHINESE PEOPLE'S LIBERATION ARMY;1994-06
6 XU RENBAO AND TAN JINXIN(Department of pathophysiology,Second Military Medical College,Shanghai);CHANGES IN GLUCOCORTICOID RECEPTOR OF LIVER CYTOSOL AFTER PATHOLOGICAL STRESS IN RATS[J];Acta Physiological Sinica;1982-04
7 SHUI LI-MING;XU REN-BAO(Department of Pathophysiology,Second Military Medical University,Shanghai200433);A QUANTITATIVE STUDY ON THE RELATIONSHIP BETWEEN THE SPECIFIC BINDING OF GLUCO CORTICOID RECEPTOR AND GLUCOCORTICOID BIOPOTENCY IN RAT THYMOCYTES[J];Acta Physiological Sinica;1991-03
8 CHEN PET-JIE;WEI JUN-WEN;FANG MTNG;XU REN-BAO Department of Rehabilitation and Sports Medicine,Shanghai Institute of Physical Education,Shanghai 200433 Depatment of Pathophysiology,Second military medical college Shanghai 200433;CHANGES IN PLASMA INTERLEUKIN-1 AND THEIR POSSIBLE RELATIONSHIP WITH THE CHANGES IN GLUCOCORTICOID RECEPTOR IN AGED LONG-DISTANCE RUNNER[J];Acta Physiological Sinica;1992-02
9 GUO XING-ZHONG;LIU YU-JIAN;WANG YI-LUN;XU REN-BAO(Department of Pathophysiology, Department of Biochemistry,Second Military Medical University, Shanghai 200433);A STUDY ON EXPRESSION OF THE HEAT SHOCK SUPPRESSED GENE IN DISTAL ORGANS OF RATS AFTER SCALDING[J];ACTA PHYSIOLOGICA SINICA;1997-04
10 WU BING-YI;SONG LIANG-NIAN AND XU REN-BAO (Department of Pathophysiology,Second Military Medical University, Shanghai 200433);INDUCTION OF HSP70 mRNA IN THE BRAIN AND LIVER OF RATS AFTER SCALDING[J];ACTA PHYSIOLOGICA SINICA;1995-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 WANG Mao-ye School of P.E.,Shandong Normal University,Jinan 250014,China.;On the Development of the Study of Sports and Psycho-neuroimmunity[J];Journal of Capital Institute of Physical Education;2007-01
2 SHEN Hai ying, ZHOU Yuan guo, LU Jing li, et al. (Research Institute of Field Surgery,Daping Hospital, the Third Military Medical University, Chongqing 400042, China);The study of glucocorticoid efficiency difference between BALB/c and C57BL/6 mice[J];Chongqing Medical Journal;2003-06
3 QU Qiang,SHI Zhong△ (Department of Emergency,Xinqiao Hospital,Third Military Medical University,Chongqing 400037,China);Changes of TNF-α,IL-1β and cortisol in serum and hepatic GR following severe traumatic brain injury[J];Chongqing Medicine;2007-18
4 ;Tongluo Sanjie tincture relieves inflammatory and bone cancer pain in rats: an abservation of outcome[J];Academic Journal of Second Military Medical University;2006-06
5 WANG Jun ping, SU Yong ping, LIU Xian hua, ZHAO Jing hong, LIU Du hu, ZHOU Yan hong, QIN Rong (Institute of Combined Injuries, Third Military Medical University, Chongqing 400038, China);Expression of glucocorticoid receptor in the liver of severe scalded rats during the early stage of stress[J];Acta Academiae Medicine Militaris Tertiae;2002-08
6 ZHOU Pin-qing Depatment of surgery,People's Hospitul of ErYuan,yunnan Eryuan 671200,china;Experience of cure on 24 cases of sever acute cholangitis[J];Hainan Medical Journal;2004-06
7 QIAN Min CHEN Dechang LIU Hongmei Department of ICU,First Hospital of Yichang,Hubei,Yichang 443000;The effects of ginsenosides on glucocorticoid receptor in post-trauma septic rats[J];Hbei Medical Journal;2005-12
8 Xu Jinyu Li Shengping Wang Hongyuan (Macun District people's Hospital Jiaozuo,Henan,454171,China);Analysis of surgical treatment of the elderly patients with ACST[J];Henan Medical Information;2002-23
9 ZHANG Jinfeng Zhengzhou The Second People's Hospital,Zhengzhou 450000,China;Analysis of Death Factors of Acute Cholangitis of Severe Type[J];Journal of Medical Forum;2005-17
10 ZHAO Yan-hong, ZHOU Jin(Department of Hematology, the First clinical hospital, Harbin Medical University, Harbin 150001,China);Expression of glucocorticoid receptors in steroid-resistant patients with idiopathic thrombocytopenia purpura[J];Basic Medical Sciences and Clinics;2005-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved