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《CHINESE JOURNAL OF PATHOPHYSIOLOGY》 1995-06
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Effects of oxy─radical and anticancer drugs on permeability of endothelial cell, on cell skeleton and cancer cell adhesion

Zhang Ya─Li, Zhou Jie, Zhou Dian─Yuan, Wu Bao─Ping Department Digestive Medicine, Nanfang Hospital, The First Military Medical University, Guangzhou (510515)  
In order to study the relationship between cancer cells and endothelialcells, the cytotoxicity induced by oxy─radical and anticancer drugs on endothelial cellpermeability, cell skeleton and cancer cell adhesion were observed based on an in vitro modelof endothelial permeability. The results showed cancer cytotoxic media could increasedthe permeability of endothelial monolayer. Morphological observation showed that thecontraction of endothelial cell and the changes of cell skeleton may partly be responsiblefor the increase of permeability. Further studies showed that the change of endothelialmonolayer could also increased the number of cancer cell adhesion onto endothelium. It issuggested that there were some relationship between injure of endothelial cell and inva─sion of cancer cells, though it should be further proved by in vivo experiment.
【Key Words】: Free radicals Endothelium Permeability Drugs Neoplasms
【CateGory Index】: R965
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【References】
Chinese Journal Full-text Database 5 Hits
1 WEI Ping,LI Qing-zhang,QU Qi-huan (Northeast Agricultural University,Heilongjiag Harbin 150030);The Action of LPO Content Induced by Astragalan and Lentinan Inparenchyma Organs of VAMV Infected Chicks[J];HEILONGJINAG JOURNAL OF ANIMAL SCIENCE AND VETERINARY MEDICINE;1999-04
2 SUN Hui-ming; SHI Yu-zhi; HUO Jian-min; WANG Min(Department of Respiratory Diseases, The First Affiliated Hospital, Harbin Medical University, Harbin 150001, China );Role of active oxygen on oleic acid-induced acute respiratory distress syndrome(ARDS )[J];JOURNAL OF HARBIN MEDICAL UNIVERSITY;1999-04
3 CHEN Hong,LI Rong-qing,DING Yun-xia,et al. Department of Oncology,Kunming General Hospital of Chengdu Military Region,Kunming,650032;The Effects of Protein Kinase C Activator Phorbol-12-Myristate-13-Acetate and Inhibitor Staurosporine on Cell Adhesion of Large Bowel Carcinoma HT-29 Cells[J];The Practical Journal of Cancer;2005-01
4 Lin Hongsheng; Li Shuqi; Piao Bingkui; et al.(The Guanganmen Hospital of the China Academia of Traditional Chinese Medicine, Beijing 100053);Studies on Regulating the Endothelial and Adhesion Molecule in Metastasis of the Lung Carcinoma by San Shen(SS) Powder[J];BULLETIN OF CHINESE CANCER;1999-12
5 Lin Hongsheng,Li Shuqi,Pei Yingxia,et al. (Guang An Men Hospital,Chinese Academy of Traditional Chinese Medicine,Beijing 111053);EFFECTS OF ACTIVE COMPONENTS TO TWO TRADITIONAL CHINESE MEDICINAL HERBS,CHUANQIONGQIN & KUSHENJIAN, ON THE ADHESION OF ENDOTHELIOCYTES TO CANCER CELL LINE(PG),ADHESION MELECULE AND PERMEABILITY OF ENDOTHELIOCYTES IN VITRO[J];CHINESE NEW DRUGS JOURNAL;1999-06
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Guo Juanjuan,Pan Xianglin,Feng Changwei,Zou Junhui (The Affiliated Hospital of Shandong Medical University,Jinan 250012,China);EFFECTS OF ORIDONIN ON INDUCING THE MULTI-DRUG RESISTANT CELL LINE K562/A02 TO APOPTOSIS AND REVERSING THEIR MULTI-DRUG RESISTANCE[J];JOURNAL OF ANHUI TRADITIONAL CHINESE MEDICAL COLLEGE;2000-03
2 Situ Rui (Dept,of Pathology Medical college, Jinan University, Guang%hou,51 O 632) James Varani(Dept .of pathology, Michigan University, Medical school);THE STUDY OF THE MOnLITY 0F HUMAN T-LYMPHOBLASTIC(JURKAT) CELL LINE[J];CHINESE JOURNAL OF CANCER;1994-02
3 ZHAO Chun-ting,YANG Chun-zheng,YANG Tian-ying,et al Institute of Hematology,CAMS and PUMC (Tianjin,300020);EXPERIMENTAL STUDY ON REVERSAL MECHANISM OF MULTIDRUG RESISTANCE BY CYCLOSPORINE A[J];Journal of Leukemia;2001-02
4 JIA Qing rui,GE Xiang hua,SUI Jin cai.Linyi People's Hospital(Linyi,276003) . [;CLINICAL STUDY OF REVERSAL EFFECT OF MULTIDRUG RESISTANCE IN ACUTE LEUKEMIA CELLS BY INTERLEUKIN-2[J];Journal of Leukemia;2003-01
5 SHI Xi kai,ZHANG Yi jun,ZHAO Chun jing (Departement of Pharmacology,Southwest Hospital,Third Military Medical University,Chongqing 400038);The effects of saponins Rb1 on the intracellular concentration of DNR in human leukemic multi-drug resistant cell K562/HHT in vitro.[J];Chongqing Medical Journal;2001-06
6 CHEN Hong-yan,WANG Chi,SHU Yan,et al.(1.Department of Otolaryngology,First Affiliated Hospital of Chongqing University of Medical Sciences,Chongqing 400016,China;2.Department of Preclinicial Medicine,Chongqing University of Medical Sciences,Chongqing 400016,China;3.Department of Otolaryngology,Children′s Hospital of Chongqing University of Medical Sciences,Chongqing 400014,China;4.Medical College of Shantou University,Guangzhou 515041,China);Effect of matrine and chemotherapeutic agents on cell cycle of KBV200 cell line[J];Chongqing Medicine;2006-15
7 JIN Yong-sheng 1, LIU Chao-mei 1, WU Qiu-ye 1, YAO Bin 1, DAI yang 2, ZHANG Lu-rong 3, Sheng Xiao-lan 1(1. Department of Organic Chemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; 2. Department of Health Service, Faculty of Health Services, Shanghai 200433; 3.Department of Oncology, Lombardi Cancer Center, Georgetown University, Washington DC 20007,USA);Design and synthesis of genistein derivatives 5-hydroxy-4’-nitro-7-substituted-acyloxo-isoflavone and their antitumor effects[J];Academic Journal of Second Military Medical University;2005-02
8 DING Yan-fang 1, XIE Xia 2, ZHAO Jin-yao 1, YANG Pei-man 1 (1.Department of Histoembryology, Dalian Medical University , Dalian 116027,China; 2. Department of Anatomy, Medical college , Dalian University, Dalian 116622,China);Reversal of adriamycin resistance by matrine in leukemia multidrug resistance cell line K562/ADM[J];Journal of Dalian Medical University;2004-04
9 XIE Xia~1,ZHAO Jin-yao~2,GAO Qing-bo~1,YANG Pei-man~2(1.Department of Human Anatomy,Medical College,Dalian University,Dalian 116622,China;2.Department of Histology and Embryology,Dalian Medical University,Dalian 116027,China);Effect of BMK on multidrug resistance reversal and glutathione s-transferase activity in human breast cancer MCF-7/ADM cell line[J];Journal of Dalian Medical University;2006-05
10 TIAN Chun Yan, ZHANG Feng Chun, LIN Yu Mei, XU Chun Yuan Department of Haematology, Zhongrilianyi Hospital, Jilin University, Changchun 132013, China;Reverse effect of Chinese Drug GLM on K562/ADM and MCF/ADM cell[J];Journal of The Fourth Military Medical University;2004-03
China Proceedings of conference Full-text Database 1 Hits
1 Zhang Jing-hong~(1,2),Li Hong-yu~(1*) (1.Life science,Lanzhou University,LanZhou,GanSu,730000,China,2.Molecular Medicine Engineering Research Central Ministry of Education,HuaQiao University,Quanzhou,FuJian, 362021,China);Study of Expression of P-pg Protein and MDRI Gene as Induced by Realgar Bioleaching Solution in K562/ADM Cell[A];[C];2009
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 QIN Kai CUI Xiao-bing XU Zhi-yong YUE Ling WEN Kan LI Wei(Pharmaceutical College,Nanjing University of Traditional Chinese Medicine,Nanjing Jiangsu 210029);Research Progress on Pharmacological Effect of Ligustrazine[J];;2009-20
2 Zhu Linping,Sun Shirun,Sun Renguang,et al Second Hospital Affiliated to Tianjian TCM University(300150);Study on Clinical Application of Activating Blood to Remove Stasis[J];Journal of Zhejiang University of Traditional Chinese Medicine;2009-04
3 SHEN Xiao-dong, SONG Guan-bin, YAN Run-bin, YANG Yang (Key Laboratory for Biomechanics and Tissue Engineering Under the State Ministry of Education, College of Bioengineering, Chongqing University, Chongqing 400030, China);Research Progress of Matrine and Oxymatirne in the Anti-tumor Mechanism[J];Journal of Chongqing University(Natural Science Edition);2005-06
4 Chen Xi Ou Yang Xue nong Chen Zhang shu Da Xi hu Fuzhou General Hospital,Department of Oncology;EFFECT OF WEITAI CAPSULE ON sCD44v6 IN PATIENT WITH GASTRIC CANCER[J];Journal of Fuzhou General Hospital;2006-03
5 YANG Chuanbiao XU KechengGuangzhou Fuda cancer hospital;Function of Anti-tumor of Chinese Medication[J];International Medicine & Health Guidance News;2004-18
6 Ling Dan, Li Li, Li Danrong, et al.(Department of Gynecologic Oncology. Guangxi Tumor Hospital, Guangxi Medical University, Nanning 530021 China);THE EFFECT OF SOPHORCARPIDINE ON THE EXPRESSION LEVELS OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR, ITS INHIBITOR PLASMINOGEN,ACTIVATOR INHIBITOR TYPE-1 AND CYTOTOXICITY TO OVARIAN CELLS IN VITRO[J];Journal of Guangxi Medical University;2007-04
7 MA Aiying~(1,2)(1.Life science school of Ningxia University,Yinchuan 750021;2.Second Northwest University for Nationalities,Yinchuan 750021);The Extraction and Separation of Alkaloids[J];Journal of Guyuan Teachers College;2006-03
8 LU Xinan.Department of Oncology,People's Hospital of Heng County,Guangxi Zhuang Autonomous Region,Heng County 530300;Investigation of the effect of Fufang Kushen Injection combined with chemotherapy and radiotherapy on advanced non-small cell lung cancer[J];Hebei Journal of Traditional Chinese Medicine;2010-10
9 LI Kang ha,LI Guo-jun,LONG Hai-tao,et al(Department of Orthopaedics,Xiangya Hospital,Central South University,Changsha 410008,China);Study on the Influence of Matrine on Exosomatic Proliferative Activity of Osteosarcomatous cell line MG-63[J];Journal of Clinical Research;2008-12
10 ;Study Progress in Effect of Chinese Herbs of Promoting blood and Eliminating Blood Stasis Kinds on Vascular Endothelial Cell[J];Guiding Journal of TCM;2005-12
China Proceedings of conference Full-text Database 2 Hits
1 Department of Oncology , Wangjing Hospital Affiliated to China Science Academy of Traditional Chinese Medicine Feng Li, Hua Bao-Jin, Piao Bing-Kui;Effects of Feiliuping Ⅱ on Expression of CD44v6 and CD49 in Plasm of Non-small Cell Lung Cancer Patients[A];[C];2006
2 ;Treating 30 cases of NSCLC in the Ⅱ and Ⅲ stage with Fufang Kushen inject plus chemotherapy[A];[C];2007
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