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Effect of cholecystokinin on SOD、MDA contents and phagocyte chemiluminescence of reversing endotoxin shock rat

Ling Yi-Ling,Huang Shan-Sheng,Zhang Jun-Lan,Wan Mei,Hao Rong-LiDepartment of Pathophysiology,Hebei Medical University,Shijiazhuang(050017)  
It has been reported that blood cholecystokinin(CCK)level was increased during endotoxemia and endotoxin shock(ES).Recently it was found in our department that CCK-8 could reverse experimental endotoxin shock.The rat model of ES(endotoxin 0.8mg/100gb.w.iv)was used to observe the changes of mean arterial pressure (MAP),blood SOD、MDA and phagocyte chemiluminescence(PCL) during CCK reversing ES.The results showed that MAP was elevated(P0.05),activity of plasma SOD was increased(P0.01),MDA content was decreased(P0.05),the background and peak value of PCL were enhanced as well as the peak time was reduced(P0.05)after CCK injecting in ES rats.It is suggested that CCK could increase SOD activity,decrease the MDA content,and enhance the functions of phagocyte during CCK reversing.ES,CCK has importent protective action in ES.
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