Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
Add to Favorite Get Latest Update

The effect and mechanism of IL-8 and NO in mediating endotoxin -induced lung injury in rabbits

YANG Guang, LI Ming-Zhen, YE Wang-Yun, Huang Guang-Ying Institute of Integraed Traditional Chinese and Western Medicine, Tongji Medical University, Wuhan (430030)  
AIM and METHOD:The rabbits model was induced by injecting E Coli endotoxin twice at 24 hours interval and acute lung injury was examined RESULTS:Interleukin-8(IL-8) nitrite/nitrate (NO 2 -/NO 3 -) levels in plasma, lung tissue and bronchoalveolar lavage fluid(BALF) increased markedly ( P 0 01) in model group, and C5a activity of plasma alsao increased markedly ( P 0 05) WBC in BALF,lung index, and lung permeability index (LPI) also increased significantly ( P 0 01) There was existed highly positive correlation between IL-8 and NO 2 -/NO 3 -,and between the change of acid phosphatase (ACP) activity in BALF and IL-8 or NO 2 -/NO 3 - respectively CONCLUSION: IL-8, NO mediates endotoxin-induced acute lung injury,and Il-8 might be an important mediator in lung injury .
【CateGory Index】: R332.2,
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 7 Hits
1 XIE Han-hua,WU Xiao-hua,YAO Yin.Department of Respiratory Medicine,The Affiliated Yanzhou Municipal First People's Hospital, Yanzhou University,Yanzhou,225001,China;Observation on Serum IL-8 Levels of Acute Lung Injury and Acute Respiratory Distress Syndrome[J];Journal of Chinese Physician;2003-03
2 WANG He-mei,HUANG Chun-qian,ZHANG Xian-cheng,QU Wen-sheng,SUN Xiao-hong, DING Ri-gao,RUAN Jin-xiu(National Beijing Center for Drug Safety Evaluation and Research,Institute of Pharmacology and Toxicology,Academy of Military Medical Sciences,Beijing 100850,China);The time-course effect of perfluoroisobutylene inhalation on endogenous nitric oxide and its synthases activity in rats[J];Bulletin of the Academy of Military Medical Sciences;2010-06
3 Luo Furong,Zhong Guangling,Chen Zhiwei,et al.Department of Anesthesiology,Foshan Hospital of TCM,Foshan 528000 CHINA;Effects of ketamine on LPS-induced acute lung injury in rabbits[J];The Journal of Clinical Anesthesiology;2006-03
4 CHEN Gang,WU Yun-fu,ZHOU Cai-cun(Department of ICU,Suzhou Municipal Hospital,Suzhou 215001);Studies on IL-8 and GM-CSF BALF of Patients with ALI[J];Chinese Journal of Hemorheology;2007-03
5 Yu Zhui 1, Xu Xiyong 1, Li Yinping 2, et al 1 Emergency Department of Zhongnan Hospital, Wuhan University,Wuhan 430071, China 2 Pathophysiology Department of Medical School, Wuhan University, Wuhan 430071, China;The Influence of Dexamethasone on the Acutely Injured Lung and the Potential Mechanisms[J];Journal of New Medicine;2004-04
6 WU Xin-zhong 1,2 , ZHUANG Jun-hua 2, CHEN Lin 2, HUANG Xian- zhang 2, LIN Lin 3, ZOU Guo-lin 1( 1College of Life Science ,Wuhan University, Wuhan 430072,China; ? 2?Department of Laboratory Science,? 3?Department of Respiratory ,Guan gdong Province Hospital of TCM, Guangzhou 510105, China);Detection of serum IFN-γ, IFN-α, NO and iNOS in patients with SARS and its clinical significance[J];Chinese Journal of Pathophysiology;2004-01
7 LI Xue-ling,HAN Ning-Lin,ZHOU Da-yong,et al The First Affiliated Hospital of Anhui College of TCM(Hefei,230031);The Effect of Clearing away Heat-Toxin Drugs on Immuno-Regulation of Rabbits with Endotoxemia[J];Journal of Emergency in Traditional Chinese Medicine;2007-06
Chinese Journal Full-text Database 10 Hits
1 YU Jun 1,XU Li-hua 2,WANG Yun 1,XIAO Yang *,YU Hong  (1 Department of Pathogenobiology,School of Basic Medical Sciences,Jilin University, Changchun 130021 China;2 Library of Xinmin Area,Jilin University) [;Experimental research on antibacterial effect of Belamcanda Chinensis DC and portulaca oleracece L on P. aeruginosa in vitro[J];;2001-02
2 LIU Chao ying 1,XU Li jun 1,DUAN Xiu mei 2 (1.Dept. of Pulmonary, The First Hospital, Jilin University, ChangChun 130021,China; 2.Central Laboratory, The First Hospital, Jilin University);Ralationship between Human Cytomegalovirus Infection in Patientswith Chronic Obstructive Pulmonary Disease and Cell-mediated Immune[J];Journal of Jilin University of (Medicine Edition);2003-04
3 Han Guodong et al. (Tianjin College of TCM, Tianjin);Observation on the Restoration-Promoting Effect of Major Chengqi Decoction on Experimental Pulmonary Damage[J];China Journal of Traditional Chinese Medicine and Pharmacy;1994-05
4 MAO Bin, LI Ting qian, CHI Huan hai, et al The First Affiliated Hospital, West China University of Medical Science (Chengdu, 610041,China);Clinical Research of Chronic Obstructive Pulmonary Disease Treated with Yu ping feng Granula[J];JOURNAL OF CHENGDU UNVERSITY OF TARDITIONAL CHINESE MEDICINE;1999-02
5 LUO Fu rong, CHEN Hui shun, LIU Huai qiong (Department of Anesthesiology, Daping Hospital, the Third Military Medical University, Chongqing 400042);Effects of ketamine on survival rate of endotoxic shock mice[J];Chongqing Medical Journal;2002-06
6 GAO Yue,HE Jian-ru,MIAO Qun.The First People's Hospital of Hangzhou, Hangzhou,310006,Chian;Changes of Activation and Apoptosis of T-lymphocyte in Peripheral Blood of Patients With COPD and Their Clinical Significance[J];Journal of Chinese Physician;2003-03
7 Chen Yulin, Wei Duo, Huan Jingning, Yi Chengdong, Li Yuanyi, Lu Chaixia, Li Zhi, Shen Hongxing (Department of Burn, Changhai Hospital, Second Military Medical University, Shanghai,200433);The plasma levels of IL-8 and VCAM-1 concentrations in different burn area patients with or without lung dysfunction[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1998-S1
8 Yang Lingshan, Chen Yulin, Ben Daofeng, Sun Jialing(Department of Burn, Changhai Hospital, Second Military Medical University, Shanghai, 200433);PMN infiltration in lung and lung injury in thermal injured rats[J];ACADEMIC JOURNAL OF SECOND MILITARY MEDICAL UNIVERSITY;1998-S1
9 Li Chunyan,Liu Lina,Lü shen, et al Department of Gastroenterology,The First Affiliated Hospital of Dalian Medical University, Dalian,China;Role of nitric oxide in ethanol-induced gastric mucosal injury in rats[J];JOURNAL OF DALIAN MEDICAL UNIVERSITY;1999-04
10 Wang Yi,Zhu Peifang,Wang Zhenguo, et al(Research Institute of Field Surgery, Third Military Medical College,Chongqing, 630042);Effects of endotoxin on calcium and calcium-calmodulin complex in endothelial cells[J];Acta Academiae Medicinae Militaris Tertiae;1992-04
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 Shi Denghan,Xu San(tutor)Zhejiang Chinese Medical University,Hangzhou(310053);Research on Relativity between NO and Functional Dyspepsia[J];Journal of Zhejiang University of Traditional Chinese Medicine;2009-03
2 ZHENG Xiu-li,FENG Quan-sheng,YANG Yu,et alChengdu University of TCM(Chengdu 610075);Effect of Sheng Ya Ling on TNF-α and iNOS in Lung Injury Rats with Endotoxic Shock[J];Journal of Chengdu University of Traditional Chinese Medicine;2008-03
3 GAN Qian-fu,LIN Zheng,LIANG Xue-wu,LIU Qing-hua,BAO Ruo-hong(Institute of Dairy Cattle,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China);The changes of HSP70 and NOS in the tissues of heat stress animals[J];Journal of Fujian Agriculture and Forestry University(Natural Science Edition);2010-03
4 XIAO Jing1,LI Xiao-li1,2,TONG Liang1,LI Yan-bing1,GUI Yi1,LI Jin-tao1,ZHANG Yi-fang1(1.Faculty of Animal Science and Technology,Yunnan Agricultural University,Kunming 650201,China;2.Yangtze River Fisheries Research Institute,Chinese Academy of Fishery Sciences,Jingzhou 434000,China);Study Progress in Bactericidal/Permeability Increasing Protein[J];China Animal Husbandry & Veterinary Medicine;2009-11
5 HU Jiu-lue,HE You-shun(TCM University of Hunan,Changsha,Hunan 410007,China);Progress in study of Chinese medicine on Endotoxemia[J];Journal of Traditional Chinese Medicine University of Hunan;2010-05
6 ZHANG De-xin,LU Ying,ZHAO Yan,et al(Department of Emergency,The Second Clinical College,Harbin Medical University,Harbin 150081,China);Comparative analysis of clinical features of mild and severe cases of Type A H1N1 influenza[J];Journal of Harbin Medical University;2010-03
7 CHEN Jian reviewing, XU Lin checking(Department of Thoracic Surgery, Jiangsu Cancer Hospital of Nanjing Medical University, Nanjing 210009, Jiangsu, China);Update of researches on acute lung injury in thoracic surgical procedures[J];Journal of Medical Postgraduates;2009-02
8 LI Li-na,WANG Qing-guo(Beijing University of Chinese Medicine,Beijing 100029);Discuss on TCM pathogenesis of acute lung injury from qi,blood and water[J];Journal of Beijing University of Traditional Chinese Medicine;2008-05
9 ZHU Min-min,ZHANG Xiao-bao,CHEN Xin-chun,et al.Department of Anesthesiology,Nanjing Medical University,Nanjing 210029, China;Effect of ketamine on OVA-induced changes of free intracellular calcium and free-radical in sensitized rat macrophage in vitro[J];The Journal of Clinical Anesthesiology;2007-04
10 QUE Jun, MEI Yong,XU Xin-rong,et al.Intensive Care Unit, First Affiliated Hospital, Nanjing Medical University,Nanjing 210029, China;Protective effects of ulinastatin combined with dexamethasone on acute lung injury induced by endotoxin in rabbits[J];The Journal of Clinical Anesthesiology;2007-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved