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《Chinese Traditional Patent Medicine》 2001-05
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Effect of LBP on Expression of c-myc Oncogene of Senile Mice

CHEN Zhi-song1, NONG Zhi-fei2, WU Zhi-kui1, CAI Yong-chun1, WANG Lei1 (1. Laboratory of Molecular Biology, Guanganmen Hospital, China Academy of Traditional Chinese Medicine, Beijing 100053, China; 2. First Affiliated Hospital of Guangxi College of  
Objective:To study the molecular mechanism of anti-senile effect of lycium barbarum polysaccharides (LBP). Methods:After natural senile mice and D-gal-induced senile mice were given LBP for two months and a month respectively, the expression changes of c-myc oncogene in marrow cells of all mice were measured by the techniques of semi-quantitative reverse transcription and polymerase chain reaction (RT-PCR).Results: The expression of c-myc oncogene of natural senile mice and D-gal's-induced senile mice were significantly higher than those of young and nomral mice (P0.001). After medication, LBP obviously inhibited the change (P 0.05).Conclusions: One of molecular mechanisms of anti-senile effect of LBP is to inhibit the expression of c-myc oncogene.
【CateGory Index】: R285.5
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