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《Chinese Traditional Patent Medicine》 2008-02
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Clinical effect of Fuzheng Jiedu Granule combined with western medicine on 60 patients with coronary heart disease long-term exposed to nickel

WEI Zi-tai~1,ZHAO Jian-xiong~2(1.Department of Medicine,Quzhou Vocational and Technical College,Quzhou 32400,China;2.Institute for Traditional Chinese Medicine and Western Medicine,Lanzhou University,Lanzhou 730000,China)  
AIM:To evaluate the clinical effect of Fuzheng Jiedu Granule(Radix Hedysari,Poria,Radix Angelicae sinensis,Fructus Forsythiae,Rhizoma Curcumae,Radix et Rhizoma Salviae miltiorrhizae,etc.) on patients with coronary heart disease who have longterm contact with nickel,and observe its influence on the level of Creatine kinase(CK),Lactate dehydrogenase(LDH),Na~+-K~+-ATPase,Ca~(2+)-ATPase in RBC membrane,Nitric oxide(NO),Nitric oxide synthase(NOS),Nickel(Ni) in serum. METHODS: 60 cases were divided into two groups A and B randomly.30 cases in group A were treated with Fuzheng Jiedu Granule combined with western medicine Betaloc and Isosorbide Dinirrate;30 cases in group B were given only western medicine.The period of treatment was 4 weeks.Another 15 healthy cases selected as group C(healthy control group).Before and after treatment,the clinical effects were observed,meanwhile,some biochemical indexes such as CK,LDH,Na~+-K~+-ATPase,Ca~(2+)-ATPase in RBC membrane,NO,NOS,Ni in serum were measured with clinic test methods.Finally,the experimental results were compared and analyzed in the three groups mentioned above. RESULTS: The therapeutic effect of symptoms and signs of group A was superior to that of group B(P0.05);compared with group C before treatment,there was a significant increase in the levels of serum CK,LDH,Ni and a significant decrease in the levels of serum NO,NOS,Na~+-K~+-ATPase,Ca~(2+)-ATPase in RBC membrane;compared with group B after treatment,the levels of serum CK,LDH,Ni in group A decreased(P0.05~0.01) significantly;Meanwhile,there was a remarkable increase in the activites of serum NO,NOS,Na~+-K~+-ATPase,Ca~(2+)-ATPase in group A(P0.05~0.01).(CONCLUSION:) Fuzheng Jiedu Granule can decrease the serum Nickel,restore the activity of cardiac enzyme,and improve patients' symptoms.
【Fund】: 甘肃省教育厅科学研究基金项目资助(No.023-01)
【CateGory Index】: R541.4
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