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《Chinese Traditional Patent Medicine》 2008-10
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Quality control of G. pentaphyllum by wavelet transform and fractal expression

LIU Fang 1,2,HU Ping 1,Annika Küster3,REN De-quan2(1.School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China;2.School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;3.Fachhochschule Lübeck,Lübeck,Germany)  
AIM:To develop the HPLC fingerprinting of Gynostemma pentaphyllum and evaluate the quality of different sources of G.pentaphyllum by fractal expression and wavelet analysis based on similarity calculation.METHODS:Flavones of G.pentaphyllum were extracted by using methanol and the HPLC fingerprint analysis on an HPLC/DAD system was developed.The signal of chromatogram was decomposed into components at different resolution by wavelet transform.Furthermore,the fractal dimensions of these components were computed for similarity calculation.RESULTS:With the optimized extraction and analytic tool,the fingerprint of G.pentaphyllum was developed.The similarity was effective in evaluating the quality of G.pentaphyllum.CONCLUSION:To describe a fingerprint profile by factors based on fractal and wavelet transform was a more objective method.G.pentaphyllum from Zhejiang province can be used as a substituent for raw drug from Ankang,Shanxi province.
【CateGory Index】: R284.1
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