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《Chinese Traditional Patent Medicine》 2009-11
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Influence of matrine on cyclin in U937 cell strain

LU Qian-wei~1,CHEN Jian-bin~(2*),TANG Wei-xue~3,LIAO Yang~2, GE Qun-fang~2,YANG Ze-song~2(1.Department of Oncology and Hematology,No.9 Chongqing People's Hospital,Chongqing 400700;2.Department of Hematology,No.1 Hospital(Affiliated) to Chongqing Medical University,Chongqing 400016;3.Department of Pathophysiology,Chongqing Medical University,Chongqing 400016,China)  
AIM: To investigate the influence of matrine on cyclin E and cyclin A in U937 cell strain. METHODS: The inhibitory effect of matrine on proliferation in U937 cell strain was observed by MTT.The distribution of cell cycle was measured by flow cytometry.Immunocytochemical method and Western blot were used to detect the protein expression of cyclin E and cyclin A. RESULTS: After being treated with matrine,the proliferation of U937 cell strain was inhibited significantly,the inhibiting effect conformed to time and dose-dependence,cells were arrested in S-phase.The expression of cyclin E and cyclin A was down-regulated significantly in a dose-dependence manner. CONCLUSION: Matrine could reduce the expression of cyclin E and cyclin A and inhibit the proliferation in U937 cell strain.
【Fund】: 重庆市卫生局科研基金课题(07-2-035);; 重庆市教委科研项目(KJ080321);; 重庆医科大学创新基金(XBYB2007024)
【CateGory Index】: R285
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