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《Chinese Traditional Patent Medicine》 2010-12
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The antitumorus and antiviral activity of total flavonoids from Senecio scandens in vitro

HE Zhong-mei1,BAI Bing2,WANG Hui3,SUN Jia-ming3,ZONG Ying1(1.College of Chinese Medicine Materials,Jilin Agricultural University,Changchun 130117;2.Novel Pharmaceutical R&D Co.,Ltd,Jilin Xiuzheng Pharmaceutical Industry Group,Changchun 130012;3.Changchun University of Traditional Chinese Medicine,Changchun 130117,China)  
AIM: To investigate the antitumorus and antiviral activity of total flavonoids from Senecio scandens in vitro.METHODS: The inhibitive effect of total flavonoids on human hepatocellular carcinoma cell line SMMC-7721,human gastric carcinoma cell line SGC-7901,human breast carcinoma cell line MCF-7 was measured by MTT assay and the inhibitive effect on human Respiratory Syneytial virus(RSV) was detected by cytopathic effect(CPE).RESULTS: Half inhibitory concentration of total flavonoids on SMMC-7721,SGC-7901,MCF-7 was 48.73,61.32,31.26 μg/mL,respectively.Half of the toxic concentration was 0.29 mg/mL,the median effective concentration(EC50) of total flavonoids on RSV was 38.3 μg/mL,the therapeutic index was 7.6.CONCLUSION: Total flavonoids from Senecio scandens has obvious antitumorus and antiviral activity in vitro.
【Fund】: 吉林省教育厅“十一五”资助项目(2009第63号);; 吉林农业大学科研启动基金资助项目(20090422)
【CateGory Index】: R285.5
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