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《Chinese Traditional and Herbal Drugs》 1996-11
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Studies on the Immuno Modulatory Action of Icarrin

Zhao Yong;Zhang Ling;Cui Zhengyan;et al(Institute of Basic,Shandong Provincial Academy of Medical Sciences,Jina)  
Icarrin is the main monomer extracted and purified from Epimedium koreanum Nakai. Using dependentcell lines and LDH release assay,the synergistic effects of icarrin on inducing IL-2, 3, 6 and enhancing NK,LAK cell activity were studied. Results showed that icarrin can induce tonsil mononuclear cells to produce IL-2, IL-3,and IL-6 in collaboration with PHA in a dose-dependent manner. IL-2 and IL-6 peaked at 48h after reaction,and IL-3 peaked at 72h. Icarrin enhanced NK and LAK cell activity dose-dependentlylthe LAK activitypeaked on the 5th day. These results suggested that icarrin may be an effective BRM agent
【Key Words】：
【Fund】： 山东省自然科学基金
【CateGory Index】： R285
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