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《CHINESE TRADITIONAL AND HERBAL DRUGS》 1997-04
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Protection of Gypenoside Against Oxygen Free Radical Induced Vasospasm of Isolated Rabbit Basilar Artery

Chen Jianxiong;Liao Duan fang;Tang Xiaoqing;et al (Address:Chen Jianxiong,Department of Pharmacology,Hengyang Medical College,Hengyang)  
Protective effect of gypenoside (GPS)against damges induced by exogenous oxygen free redicals (OFR)on rabbits basilar artery was studied. Exogenous OFR were generated by electrolysis of Krebs solution. The perfusion pressure and malonyldialdehyde (MDA)content in basilar artery were increased, release of Endothelium-derived relaxing factor (EDRF), nitrite content and SOD activity in basilar artery decreased afer OFR damage. GPS 25, 50, 100 μg/mL pretreatment exhibited a concentration dependent decrease in constriction response of basilar artery. Results also showed that GPS 100μg/mL reversed the rise of MDA and the reduction of SOD activity,nitrite and EDRF release.
【Fund】: 湖南省自然科学基金
【CateGory Index】: R285
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