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《CHINESE TRADITIONAL AND HERBAL DRUGS》 1998-01
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A New Indole Derivative Isolated from the Root of Tuber Fleeceflower(Polygonum multiflorum)

Yang Xiuwei;Gu Zheming;Ma Chaomei;Masao Hattori;Tsuneo Namba  
From the root of Polygonum multiflorum Thunb. f a new indole derivative,named In dole- 3 (L-α-amino-a-hydroxy propionic acid)methyl ester (Ⅺ), was isolated together with the ten known compounds,chrysophanol (Ⅰ), physcione (Ⅱ), emodin (Ⅲ),citreorosein (Ⅳ), chrysophanol 8-O-β-D-glucopyranoside (Ⅴ), physcione 8-O-β-D-glucopyranoside (Ⅵ),emodin 8-O-β-D-glucopyranoside (Ⅶ), torachrysone 8-O-β-D-glucopyranoside (Ⅷ), 2, 3, 5, 4' -tetrahydroxystilbene2-O-β-Dglucopyranoside(Ⅸ),and methylgallate (Ⅹ). Their structures were determined by spectroscopic means. These anthraquinone compounds and aloe-emodin(Ⅻ),rhein(Ⅻ),aloe-emodin 8-O-β-D glucopyranoside, chrysophanol 8-O-β-D- (6'-O-malonyl)glucopyranoside , sennoside A and sennoside B had no inhibitory effect against recombinant HIV-1 protease at concentration of 100 μmol/L in vitro.
【Key Words】： Root of Polygonum multiflorum Indole derivative Indole-3 (L-α-amino-α-hydroxy propionic acid)methyl ester Recombinant HIV-1 protease
【CateGory Index】： R282
【DOI】： CNKI:SUN:ZCYO.0.1998-01-002
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