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《Chinese Traditional and Herbal Drugs》 2004-11
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Biothermokinetic studies on four properties of traditional Chinese materia medica——Comparison of different preparation properties of Coptidis Rhizoma by microcalorimetry

ZHOU Shao-hua1, PAN Wu-jiu, XIAO Xiao-he, ZHAO Yan-ling1, LIU Yi3 (1. Department of Pharmacy of No. 302 Hospital of People's Liberation Army,Beijing 100039, China; 2. Academy of Military Medical Sciences of People's Liberation Army, Beijing 100850, China; 3. Department of Chemistry, Wuhan University, Wuhan 430072, China.)  
Object To probe into the objectivity and authenticity of four properties (cold, heat, warm, and cool) of raw Coptidis Rhizoma (RCR) and their preparations from biophysics and biochemistry. Methods Microcalorimetry was used to obtain the metabolic growth power-time curve of bacteria affected by the total alkaloid in different preparations of RCR and biothermokinetic parameters. Combined with the records of ancient herbal literatures, the influence of properties by different preparations to RCR were synthetically evaluated. Results All the effective total alkaloid in different preparations of RCR can restrain the Escherichia coli growth and metabolism in different level. Drugs, such as Coptidis Rhizoma Stir-fried with ginger juice (CRGJ), Coptidis Rhizoma stir-fried with wine (CRW), and Coptidis Rhizoma stir-fried with Fructus Evodiae (CRFE), with a little Warm Property can decrease the multiplication rate constants of E. coli index and increase heat output in growth metablism remarkably, while the drugs, such as RCR, Coptidis Rhizoma stir-fried with vinegar (CRV), and Coptidis Rhizoma stir-fried with gallbladder juice (CRGBJ), with a little Cold Property can decrease the multiplication rate constants and increase heat output a little. There was a stable difference between them. Conclusion Microcalorimetry is a new and useful mean for the study of the properties of tradition Chinese medicine.
【Fund】: 国家自然科学基金资助项目 (C0 3 0 3 0 2 0 8 3 9970 911)
【CateGory Index】: R285
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