Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Traditional and Herbal Drugs》 2010-12
Add to Favorite Get Latest Update

Protection and mechanism of Di′ao Xinxue Kang against myocardial ischemia-reperfusion injury in rats

CHEN Hong1,ZHU Kun-peng1,ZHANG Zhen2,YU Lei2,KANG Yi3,LIU Xin4(1.Department of Pharmacy,Affilliated Hospital,Medical University of Chinese People′s Armed Police Forces,Tianjin 300162,China;2.Department of Academic,DI′AO Group,Chengdu 600041,China;3.Department of Pharmacology,Tianjin Medical University,Tianjin 300070,China;4.Department of Pathophysiology,Tianjin Medical University,Tianjin 300070,China)  
Objective To observe the cardioprotective effect of Di′ao Xinxue Kang(DAXXK) and to explore the mechanisms on myocardial ischemia-reperfusion(I/R) injury in rats.Methods The myocardial ischemia reperfusion injury model was established by the ligation of left descending coronary artery for 30 min and reperfusion for 120 min in rats.By using it,the effects of DAXXK different dosage groups on the ST segment of ECG,onset and duration of ventricular arrhythmia(VA),the score of arrhythmia,and the effects on myocardial infarction size and morphologic change after myocardial injury in rats were observed.Myocardial apoptosis was detected using TUNEL method.Expressions of apoptosis-associated protein Fas and FasL were measured using the immunohistochemical method.Total-superoxide dismutase(T-SOD) was detected by spectrophotometer.NO and ET-1 in serum were detected by ELISA.Mn-SOD mRNA was measured by RT-PCR method.Results Compared with I/R group,DAXXK with dose-dependent brought down the ST segment,decreased score of arrhythmia,diminished myocardial infarction size and decreased myocardial swelling,interstitial hemorrhage,and inflammatory cell infiltration,as well as a markedly improved cardiac function.Compared with I/R group,apoptosis was decreased,positive indexes of Fas and FasL were lessened.The myocardial antioxidative activity after myocardial I/R injury was increased and vascular endothelial function was improved by DAXXK in a dose-dependent manner.Conclusion DAXXK could protect myocardium against I/R injury.The protective mechanisms could involved in the myocardial antioxidative activity,antiapoptosis action,and improvement of vascular endothelial function.
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 4 Hits
1 ZHANG Guang-mou,WANG Wen-feng,WANG Xing-ping,XU Chong-jie,ZHANG Yan-fen(Department of Cell Biology and Genetics,Xinxiang Medical College,Henan Xinxiang 453003 China);The Myocardial Apoptosis and the Expression of Fas and FasL Genes in Ischemic Myocardium of Rats[J];Progress of Anatomical Sciences;2009-01
2 GAO Wei-zhen WANG Wei FAN Xiao-jin KANG Yi ZHAO Yun-qian YU Lei ZHANG Zhen WU Yan-na LIU Yan-xia LOU Jian-shi GAO Wen-yuan. Pharmacology department Tian-jin Medical University,Tian-jin,300070,China;The Protective Effect of Dioscin on Cultured Cardiomyocytesin Anoxia/Reoxygenation Injury[J];Molecular Cardiology of China;2008-02
3 LIU Suixin, SUN Ming, LI Tong. Department of Cardiac Rehabilitation Center, XiangYa Hospital, Central South University,Changsha 410008,China;The effect of anoxic injury and the dioscornin intervention on intracellular calcium concentration and SERCA2 expression of myocardial cells[J];Chinese Journal of Cardiology;2004-09
4 TANG Shi-rong,YANG Ru-tong,PAN Fu-sheng,ZHAO Ai-ming,PANG Zi-jie(Institute of botany,Jiangsu Province and the Chinese Academy of Sciences,Nanjing 210014,China);Steroidal saponin and steroidal sapogenin in Chinese Dioscorea L.[J];Journal of Plant Resources and Environment;2007-02
Chinese Journal Full-text Database 10 Hits
1 LIU Guo-chen1,LI Sheng-yu2,HE Da-jun2,ZHAO Xue-song2,SUN Fang2,ZHOU Yi-fa2(1.Chaoyang Teachers' College,Chaoyang 122000,China;2.School of Life Sciences,Northeast Normal University,Changchun 130024,China);Selectively acidic hydrolysis of steroidal saponins[J];Journal of Northeast Normal University(Natural Science Edition);2007-02
2 ZHENG Xiaoqun Department of Cardiology,the First Affiliated Hospital,Dalian Medical University,Dalian 116011 YU Qin Department of Cardiology,Zhongshan Hospital Affiliated to Dalian University,Dalian 116001 FANG Weiyi Department of Cardiology,Shanghai Hospital of Thorncic Disease,Shanghai Jiaotong University,Shanghai 200030;Effects of Dioscin in Protection of Myocardial Ischemic Reperfusion Injury in Wistar Rats[J];Chinese Journal of Clinical Medicine;2006-03
3 YU Qin1 FANG Weiyi2 ZOU Yunzeng3 ZHU Ning4 ZHENG Xiaoqun5 1.Affiliated Zhoshan Hospital of Dalian University,Dalian 116001;2.Shanghai Chest Hospital Attached Shanghai JiaoTong University,Shanghai 200030;3.Zhongshan Hospital,FuDan University,Shanghai 200032;4.The Second Affiliated Hospital of Dalian Medical University,Dalian 116023;5.Changchun Central Hospital,Changchun 130051;An Anti-apoptosis Study on Mesenchymal Stem Cells with Dioscin[J];Chinese journal of Clinical Medicine;2008-06
4 MA Gui-xi,LI Ming-gao,HAN Lei,HUANG You-zhang(Navy General Hospital,Beijing 100037,China);EFFECT OF ANGIOTENSINⅡ ON INTRACELLULAR Ca~(2+) CONCENTRATION OF VASCULAR ENDOTHELIAL CELLS AND PROTECTION OF DILTIAZEM UNDER HYPOXIA[J];Journal of Preventive Medicine of Chinese People's Liberation Army;2009-05
5 ZHANG Nan ZHANG Jie GE Hai-tao Yellow-River Institute of Materia Medica,Nanjing University;Advance in Dioscin and Its Hydrolysate in Treating Cardiovascular Diseases[J];Shanghai Journal of Traditional Chinese Medicine;2009-09
6 ZHAO Yun-qian,KANG Yi,GAO Wei-zhen,WANG Wei,FAN Xiao-jing,LOU Jian-shi.Department of Pharmacology,Tianjin Medical University,Tianjin 300070,China;Cardioprotective effects of dioscin against myocardial ischemia reperfusion injury in rats[J];Chinese Journal of Cardiovascular Medicine;2008-06
7 Wu Yuling1,Peng Xiangping2,Wu Feifei3(1.The Second Affiliated Hospital,Chongqing University of Medical Sciences,Chongqing,China 400010;2.Chongqing Institute of Chinese Medicine,Chongqing,China 400013;3.Zhongshan Hospital of Chongqing,Chongqing,China 400013);Observation of Therapeutic Effects of Wenxin Granule on Coronary Heart Disease with Frequent Premature Ventricular Contractions[J];China Pharmaceuticals;2006-20
8 Lu Shu // The Wuxi TCM Hospital(Wuxi 214001);Study on Protective Effect of Chinese Herbal Medicine on Myocar-dial Damage by Calcium Overload[J];Chinese Journal of Integrative Medicine on Cardio-/Cerebrovascular Disease;2005-01
9 Wang Lingfang,Zhao Yunqian,Gao Weizhen,Lou Jianshi,Kang Yi(Dept of Pharmacology,Tianjin Medical University,Tianjin 300070);Dioscin increased antioxidative ability of myocardium after ischemia-reperfusion injury in rat[J];Pharmacology and Clinics of Chinese Materia Medica;2009-05
10 QI Zhi,LI Jing-ping (Department of Cardiology,The 309 Hospital of PLA,Beijing 100091,China);Dioscornin tablets in the treatment of acute non-ST elevation myocardial infarction[J];Acta Academiae Medicinae CPAF;2010-04
China Proceedings of conference Full-text Database 1 Hits
1 LIU Tao-bo (Graduate department,Chengdu Sport University,Chengdu 610041);Exercise and sarcoplasmic reticulum calcium-ATPase[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Chen Hongqin1,et al Department of Cardiovasology,Southwest Hospital;THE EFFECTS OF HYPOXIA ON L-TYPE Ca~(2+) CHANNEL OF CARDIAC MYOCYTE IN RATS[J];Journal of High Altitude Medicine;2001-02
3 YANG Yong-jie~1, ZHENG Guang-shun~2, GUAN Jun-hong~1, FANG Xiu-bin~(2*)(1.Department of Neurosurgery, The Second Clinical College;2.Department of Neurobiology, Basic Medical College, China Medical University, Liaoning Shenyang 110001 China);The Effect of Calcitonin Gene Related Peptide on the Expression of Fas mRNA in the Hippocampus during Focal Cerebral Ischemia/Reperfusion in Rats[J];Progress of Anatomical Sciences;2005-03
4 HU Jun,YANG Jin,ZHAO Jin-yao,JIN Wei,SONG Yang,YANG Pei-man,SHAO Shu-juan~*(Department of Histology and embryology,Dalian Medical University,Liaoning Dalian 116027 China);The Different Expression of E-cadherin in High and Low Metastatic Human Ovary Serous Cystadenocarcinoma Cell Strains[J];Progress of Anatomical Sciences;2006-03
5 LI Yan-ping1,SHI Fu-jun2,CAO Xing-yuel,WANC Yan-li3 (Department of Histology and Embryology,Xinxiang Medical College,Henan Xinxiang 453003 China);Expression and Significance of fas,FasL and P53 in Breast Cancer of Human[J];Progress of Anatomical Sciences;2007-02
6 Peng Zhanglong,Hang Yannan,Sun Dajin Department of Anesthesiology,Renji Hospital,Shanghai Second Medical University,Shanghai 200001;Effect of Nicardipine on Anoxia Reoxygenation Injury and Intracellular Calcium in Primary Culture Myocardial Cells[J];THE JOURNAL OF CLINICAL ANESTHESILOLGY;2000-07
7 Li Zipu, Liu Yuyang, Gu Juanhong,et al(Department of Pedialrics, Children's Hospital, Shanghai Medical University;Shanghai 200032);The influence of calcium antagonist used prophylactically on myocyte and erythrocyte calcium in ischemic rat[J];SHANGHAI MEDICAL JOURNAL;1997-05
8 ZHOU Xiu-hua~*,ZHANG Ru-xin,LI Dong-mei.~*Department of Cardiology,Forth Affliated Hospital of China Medical University,Shenyang 110032,China;Effects of ramipril on expression of Fas/FasL genes in experimental hypertensive Wistar rats[J];Shanxi Medical Journal;2006-07
9 CUI JIE; YAN LI; SHAOBAI XUE(Biology Department, Beijing Normal University, Beijing100875, China.) (Meridian Instruments (H K. (LTD), Unit 806, 8/F.,Cheung TAT Centre, 18 Cheung Lee Street, Shai Wan,Hong Kong.);Visualization of Golgia apparatus as an intracellular calcium store by laser scanning confocal microscope[J];细胞研究(英文版);1995-02
10 XU Ji-Min, HUANG Zhen-Hua, CHEN Yuan-Mei1 (Cardiovascular Research Section, Cardiac Function Section, Ninth Peoples Hospital, Shanghai Second Medical Unizersity, Shanghai 200011);Treatment of angina pectoris with Di-ao-xin-xue-kang capsule[J];;1993-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved