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《Chinese Traditional and Herbal Drugs》 2010-12
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Protection and mechanism of Di′ao Xinxue Kang against myocardial ischemia-reperfusion injury in rats

CHEN Hong1,ZHU Kun-peng1,ZHANG Zhen2,YU Lei2,KANG Yi3,LIU Xin4(1.Department of Pharmacy,Affilliated Hospital,Medical University of Chinese People′s Armed Police Forces,Tianjin 300162,China;2.Department of Academic,DI′AO Group,Chengdu 600041,China;3.Department of Pharmacology,Tianjin Medical University,Tianjin 300070,China;4.Department of Pathophysiology,Tianjin Medical University,Tianjin 300070,China)  
Objective To observe the cardioprotective effect of Di′ao Xinxue Kang(DAXXK) and to explore the mechanisms on myocardial ischemia-reperfusion(I/R) injury in rats.Methods The myocardial ischemia reperfusion injury model was established by the ligation of left descending coronary artery for 30 min and reperfusion for 120 min in rats.By using it,the effects of DAXXK different dosage groups on the ST segment of ECG,onset and duration of ventricular arrhythmia(VA),the score of arrhythmia,and the effects on myocardial infarction size and morphologic change after myocardial injury in rats were observed.Myocardial apoptosis was detected using TUNEL method.Expressions of apoptosis-associated protein Fas and FasL were measured using the immunohistochemical method.Total-superoxide dismutase(T-SOD) was detected by spectrophotometer.NO and ET-1 in serum were detected by ELISA.Mn-SOD mRNA was measured by RT-PCR method.Results Compared with I/R group,DAXXK with dose-dependent brought down the ST segment,decreased score of arrhythmia,diminished myocardial infarction size and decreased myocardial swelling,interstitial hemorrhage,and inflammatory cell infiltration,as well as a markedly improved cardiac function.Compared with I/R group,apoptosis was decreased,positive indexes of Fas and FasL were lessened.The myocardial antioxidative activity after myocardial I/R injury was increased and vascular endothelial function was improved by DAXXK in a dose-dependent manner.Conclusion DAXXK could protect myocardium against I/R injury.The protective mechanisms could involved in the myocardial antioxidative activity,antiapoptosis action,and improvement of vascular endothelial function.
【CateGory Index】: R285.5
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