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《Chinese Traditional and Herbal Drugs》 2012-01
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Basic property of baicalin-phospholipid complex

SHI Ya-jun1,3,WU Pin-jiang1,XU Run-chun1,LIN Yan-jun1,MA Hong-yan1,YANG Ming1,2 1.College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611137,China 2.Key Laboratory of Modern Preparation of TCM,Ministry of Education,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China 3.College of Pharmacy,Shaanxi University of Traditional Chinese Medicine,Xianyang 712046,China  
Objective To investigate the basic property of baicalin complex with phospholipid.Methods To study the baicalin complex with phospholipid by means of IR,1H-NMR,quantum chemistry,dissolubility,and the property of permeation membrane.Results The result of IR indicated that spectrogram of baicalin complex with phospholipid had the same tendency in property with baicalin and mixture.While the peak shape and wave number of-C=O,-N-H appeared abnormal.The 1H-NMR indicated that the phospholipid complex did not produce new chemical bonds between the two molecules.But the peak shape and chemical shift produced a certain change.The quantum chemistry result revealed that the two molecules did not form new compounds.On the basis of space matching,the two formed a relatively stable spatial relation by a weaker atomic orbitals overlap method.The solubility of baicalin was significantly improved,the permeation membrane ratio of baicalin was boost.Conclusion The formation of baicalin-phospholipid complex does not produce new chemical bonds.The two form a relatively stable complex by some weak interaction force.The physicochemical properties and biological characteristics of the complex are greatly improved.
【Fund】: 国家重大新药创制专项(2009ZX09103-353);; 陕西省教育厅科研专项资助(11JK0680)
【CateGory Index】: R283.6
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