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《Chinese Traditional and Herbal Drugs》 2012-12
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Effects of preparation methods and technologies on in vitro characteristics of curcumin-phospholipid complex-chitosan microspheres

TANG Qin,SUN Xiao-hui,CHEN Hao,XU Xiao-yu,ZHANG Ji-fen The Engineering and Technology Center of Efficacy Evaluation in Chongqing,College of Pharmaceutical Sciences,Southwest University,Chongqing 400715,China  
Objective In order to improve the bioavailability of curcumin(Cur) after ig administration,the curcumin-phospholipid complex-chitosan microspheres(Cur-PC-CMs) was developed and their preparation method and technology were optimized.Methods The Cur-PC-CMs were prepared by ion gel method [dropping(D) and injection(I) methods] and emulsion(E) cross-linking method.The effects of technological parameters on drug loading and releasing rate were compared.The microspheres prepared by different methods were characterized.Results SEM,DSC,and IR verified that all Cur-PC-CMs prepared by the three methods were spherical and Cur was distributed in CMs in the form of PC.The drug loading of Cur-PC-CMs prepared by ion gel method(dropping method) was over 5%,but the size was as large as(1.11 ± 0.08) mm with no bursting release and the accumulative release amount increased smoothly.The smallest microspheres were prepared by ion gel method(injection method),the size was(16.19 ± 4.91) μm and drug loading was also over 5%.The Cur could be released totally with a weak bursting release.The microspheres prepared by emulsion cross-linking method had middle size with(77.48 ± 19.37) μm,while the drug loading was only about 1%.The bursting release was strong but the release amount was the lowest.The release principals of CMs were not changed with the existence of PC and all the drug release fitted to the Weibull distribution.Conclusion The ion gel method(injection method) is more suitable to prepare PC in CMs loading Cur than the other methods.
【Fund】: 重庆市自然科学基金(csct2011jjA0324);; 重庆市卫生局中医药科技研究计划项目(2010-2-144)
【CateGory Index】: R283
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