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《Chinese Traditional and Herbal Drugs》 2013-20
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Preliminary study on serum pharmacochemistry of petroleum ether fraction in ethanol extract from Xiaoyao Powder based on UPLC-PDA

LIU Jia-li;YANG Lan;CUI Jie;GUO Bing-rong;QIN Xue-mei;GAO Xiao-xia;Modern Research Center for Traditional Chinese Medicine,Shanxi University;College of Chemistry and Chemical Engineering,Shanxi University;  
Objective To study the adscription and identification of transitional constituents in serum of rats after ig administration of petroleum ether fraction in ethanol extract from Xiaoyao Powder(XYP-A).Methods A UPLC-PDA method was established to identify the active components in serum of rats after ig administration of XYP-A and the single preparations of Bupleuri Radix(BR)Angelicae Sinensis Radix(ASR),and Atractylodis Macrocephalae Rhizoma(AMR).The transitional constituents were analyzed by comparing the fingerprints of the serum samples in formula,the single preparations and reference substances,referring literature,retention time,and UV scan spectra.Results Twenty components including 12 original components from XYP-A and eight metabolites were detected in serum of rats after ig administration of XYP-A.The original components consisted nine derived from BR,two from ASR,one from AMR,and the structures of ligustilide,atractylenolide II,2,8,10-pentadecatriene-4,6-diyne-1-ol(CH-1),and bupleurynol(CH-2) were identified.Conclusion The method is successfully applied for the serum pharmacochemistry study in rats.Twenty transitional constituents are absorbed into serum of rats and their metabolites may be the effective constituents of XYP-A acting directly to the body,which could lay the foundation for the serum pharmacodynamic study.
【Fund】: 国家自然科学基金项目(81001688);; 国际科技合作项目(2011DFA32630);; “重大新药创制”科技重大专项(2012ZX09103201-035);; 山西省基础研究青年科技研究基金(2011021007-1);; 山西省高等学校中青年拔尖创新人才支持计划资助项目
【CateGory Index】: R284
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【Citations】
Chinese Journal Full-text Database 6 Hits
1 WANG Yan-nan,DU Jun-rong(West China School of Pharmacy,Sichuan University,Chengdu,Sichuan,610041 P.R.China);Study on the effect of Z-ligustilide on rats with tMCAO and the mechanism of its anti-inflamatory[J];West China Journal of Pharmaceutical Sciences;2010-06
2 Wang Xijun(Heilongjiang University of Traditional Chinese Medicine, Harbin 150040);Studies on Serum Pharmacochemistry of Traditional Chinese Medicine[J];;2002-02
3 Chang Cunku,Wang Xijun(Heilongjiang University of Chinese Medicine,Harbin 150040,China);Contribution of Theories and Methods of TCM Serum Pharmacochemistry[J];World Science and Technology(Modernization of Traditional Chinese Medicine and Materia Medica);2010-04
4 REN Yan-ling1,2,ZHOU Yu-zhi1,MA Zhi-jie1,2,QIN Xue-mei1,2(1Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;2College of Chemistry and Chemical Engineering,Shanxi University);The fingerprint analysis of antidepressant fraction of Xiaoyaosan[J];Journal of Shanxi Medical University;2011-08
5 REN Yan-ling1,2, JIA Guang-cheng1,2, MA Zhi-jie1,2, CUI Jie1,2, ZUO Ya-mei1,2, QIN Xue-mei1,2, ZHOU Yu-zhi1* (1.Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China;2.College of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China);Screening of Antidepressant Fractions from Xiaoyaosan[J];Lishizhen Medicine and Materia Medica Research;2012-11
6 GUO Xiao-qing1,2,TIAN Jun-sheng1,SHI Bi-yun1,2,XING Jie1,JIA Jin-ping1,ZHANG Li-zeng1,QIN Xue-mei1 1.Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China 2.College of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China;~1H-NMR metabonomics on antidepression of Xiaoyao Powder composed of Bupleurum scorzonerifolium or Bupleurum chinense[J];Chinese Traditional and Herbal Drugs;2012-11
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 XU Li,SHI Le,XU Li(Nanjing University of Traditional Chinese Medicine,Nanjing 210046,China);Research methods on material basis of traditional chinese medicine compound[J];Anhui Medical and Pharmaceutical Journal;2010-01
2 ZHENG Shi-rui,LI Jun,SONG Jue(School of Pharmacg,Anhui Medical University,Provincial Laboratory of The Activity Research of Natural Medicines in Anhui,Three-level Laboratory of Scientific Research of Traditional Chinese Medicine of State Administration of Traditional Chinese Medicine of People's Republic of China "Pharmacology of Traditional Chinese Medicine",State and Provincial Key Laboratony,Hefei,Anhui 230032,China);The new ideas about the pharmacokinetics study of traditional Chinese compound medicine[J];Anhui Medical and Pharmaceutical Journal;2010-11
3 Zhan Hongsheng Zhejiang College of TCM,Hangzhou(310009);Experimental Method of Medicinal Serum and Its Application Prospects in the Study and Making of New Chinese Drugs[J];JOURNAL OF ZHEJIANG COLLEGE OF TCM;2000-02
4 MIAO Chun sheng 1, ZHAO Li yan 2, ZHAO Xue mei 1, ZHANG Xiu yun 1, LI Cai 1* (1.Dept.of Pathology, Institute of Frontier Medical Sciences, Jilin University, Changchun 130021, China;2.Dept. of Laboratory,The Second Hispital, Jilin University);Study on Inhibitory Effect of Tangshen′an on Glycation in Vitro[J];Journal of Jilin University of (Medicine Edition);2003-06
5 NU Feng-lan,DONG Wei-yan,SONG Li-jun,et al;HPLC analysis of migration components in serum from Strengthening Body Resistance Liver Healthy Pill[J];Journal of Jilin University(Medicine Edition);2008-03
6 WANG Tong-sheng,XIE Ming,ZHANG Yan-xia,YAN Yue(Beijing University of Chinese Medicine,Beijing 100029,China);Changes of ethology and monamine transmitter in stagnation of liver qi model rats and intervention of bupleurum root[J];China Journal of Traditional Chinese Medicine and Pharmacy;2008-10
7 WANG Fu-gang1,2, CAO Juan1, LIU Bin2, WANG Wei2 (1Taishan Medical University, Taian 271016, China; 2Beijing University of Chinese Medicine, Beijing 100102, China);Study on adscription of plasma effective constituents of Beagle dogs after administrated with the extract of Polygonum multiflorum Thunb[J];China Journal of Traditional Chinese Medicine and Pharmacy;2010-08
8 ZHONG Xun-long1, GUO Jiao1, 2, DING Jin-long1, HE Wei1( 1Key Unit of Modulating Liver to Treat Hyperlipemia SATCM, Three-level laboratory of Lipid Metabolism SATCM, Institute of Chinese Medical Science of Guangdong Pharmaceutical University, Guangzhou, 510006, China; 2Guangzhou University of Chinese Medicine, Guangzhou, 510006, China );Serum pharmacochemistry study on Fufang Zhenzhu Tiaozhi Capsule[J];China Journal of Traditional Chinese Medicine and Pharmacy;2011-06
9 LIU Jun,CHEN Xing,ZHANG Yi,et al(School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education,Chengdu,611137);Preliminary Study on Serum pharmacochemistry of Herpetospermum Caudigerum[J];Journal of Chengdu University of Traditional Chinese Medicine;2010-02
10 SONG Wei-xi1,HU Sui-yu2(1.The Clinical Teaching and Research Department of The Combining Chinese and Western Medicine College Affiliated Hunan University of Chinese Medicine,Changsha 410208,China;2.The Xiangya Hospital,Central South University,Changsha 410008,China);Effects of Xiaoyao pills on expression of synapsin mRNA in hippocampus of depression model rats[J];The Chinese Journal of Clinical Pharmacology;2010-01
China Proceedings of conference Full-text Database 5 Hits
1 Liu Kai-yong~1 Zeng Zhen-ling~2 (1 Department of Food Safety,He Nan university of Science and Technology,Luoyang,471003; 2 College of Veterinary Medicine,South of china Agricultural University,Guangzhou,510642);HPLC-MS Method for the Serum-pharmachemsitry Study in Chicken Serum after Oral Administration of Andrographitis Super Fine Powder[A];[C];2008
2 HONG Yan-long1,YUAN Ying2,LIN Xiao1,2*, FENG Yi1,XU De-sheng3,Wang yi-han2 (1. Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education, Shanghai University of TCM, Shanghai 201203, China;2. School of Pharmacy, Shanghai University of TCM, Shanghai 201203, China; 3. Shuguang Hospital, Shanghai 200021, China);Study on the bioactive components in Dachuanxiong Fang by serum pharmacochemistry[A];[C];2009
3 HONG Yan-long1,YUAN Ying2,LIN Xiao1,2,FENG Yi1,XU De-sheng3,Wang yi-han2 (1. Engineering Research Center of Modern Preparation Technology of TCM of Ministry of Education,Shanghai University of TCM,Shanghai 201203,China;2. School of Pharmacy,Shanghai University of TCM,Shanghai 201203,China; 3. Shuguang Hospital,Shanghai 200021,China);Study on the bioactive components in Dachuanxiong Fang by serum pharmacochemistry[A];[C];2010
4 WANG Yu, YANG Yong-qing, Chen Han-ping, CUI Jian-mei, MA Shu-lan. (Shanghai Institute Research of Acupuncture and Meridians, Shanghai, 200030; Shanghai University of Traditional Chinese Medicine, Shanghai, 200030; Shanghai Medical Collage of Fudan University, 200032, China. *.the Communication Author);The Advance of Acupuncture-serum Research[A];[C];2006
5 Li zong yang,Liu xin min,Sun xiu ping,Guo zhi,liu ya min,Pan rui le Institute of Medicinal Plant Development,Chinese Academy of Medical Science,Peking Union Medical College,Beijing 100193,China;Total saikosaponins from Buplerum yinchowense against corticosterone-induced neurotoxicity in PC12 cells[A];[C];2012
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Huang Peishan The Fourth People′s Hospital of Shantou,Shantou,Guangdong,China 515021;Research Progress of Chaihu Shugan San Combined with Antidepressant Drugs in the Treatment of Depressive Disorder[J];China Journal of Chinese Medicine;2012-05
2 GUO Rong-juan OUYANG Shuai- ling Cui Li-feng Neurology Department of Dongfang,Beijing University of TCM,Beijing 100078,China;Review of the present situation of TCM research on depression[J];Global Chinese Medicine;2009-01
3 JING Xia1,HE Zai-an2,LIU Yan-wen2(1.Jiangmen DeXin Dharmaceuticd,CD.LTD,Guang Dong JiangMen 529100;2.Hubei College of Traditonal Chinese Medicine,Wuhan,Hubei,430061);The Pharmachemical Research on the Blodd Serum of[J];Journal of Hubei College of Traditional Chinese Medicine;2007-04
4 YANG Chang-ming1, CHEN Yu-ping2, SHI Ren-bing 2#, LI Xiao2, LIU Bin2, SUN Jian-ning2, FENG Chang-gen1 (1 School of Mechatronic Engineering, Beijing Institute of Technology, Beijing 100081) (2 Beijing University of Chinese Medicine, Beijing 100102);Serum pharmacochemistry of Xingnao Gutta Pills(I)[J];Journal of Beijing University of Traditional Chinese Medicine;2006-09
5 Ou yuqing,et al;Simultaneous measurement of four monoamine neurotransmitters in rat brain by the Fluorescence method[J];Heilongjiang Medicine and Pharmacy;1998-05
6 JIA Guang-cheng1,2,TIAN Jun-sheng1,ZHOU Yu-zhi1,LI Jin-bing1,2,GUO Xiao-qing1,2, LI Yin-sheng1,2,QIN Xue-mei1(1.Modern Research Center for Traditional Chinese Medicine,Shanxi University,Taiyuan 030006,China; 2.College of Chemistry and Chemical Engineering,Shanxi University,Taiyuan 030006,China);Screening Study for Anti-Depression Effect of Xiaoyao Powder Prescriptions and Their Separated Parts[J];Liaoning Journal of Traditional Chinese Medicine;2012-01
7 WU Feng,KONG Ling-tao,TANG Yan-qing.Department of Psychiatry,the First Affiliated Hospital of China Medical University,Shenyang 110001,China;Effects of Fluoxetine and Tianeptine on the Expression of PKC in Hippocampus of Chronic Stress Depression Rats[J];Chinese General Practice;2012-12
8 Wang Xijun(Heilongjiang University of Traditional Chinese Medicine, Harbin 150040);Studies on Serum Pharmacochemistry of Traditional Chinese Medicine[J];;2002-02
9 Wang Xijun,Chen Xi,Yang Ge,Ying Jingchelang(College of Pharmacy,Heilongjiang University of Chinese Medicine,150040 Harbin)Cao Hongxin(China Academy of Chinese Medical Science,100700 Beijing);A Qualitative & Quantitative Analysis:Migrating Constituents of Zhizhu Pills in Rat Blood[J];World Science and Technology-Modernization of Traditional Chinese Medicine and Materia Medica;2007-02
10 SUN Yu-yang, LIU Jian-xun, WU Xiao-yang, et al (Experiment Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China);Study on Serum Pharmacochemistry of Shuangshenningxin Fang and its Protective Effects on Cultured Cardiomyocytes Injured by Hypoixa and Reoxygenation[J];Chinese Journal of Information on Traditional Chinese Medicine;2006-05
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