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《Chinese Traditional and Herbal Drugs》 2014-13
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Chemical constituents from Guanxinning Injection

RUAN Ming;KONG Ling-yi;LUO Jian-guang;School of Biochemical and Environmental Engineering,Nanjing Xiaozhuang University;College of China Marteia Medica,China Pharmaceutical University;  
Objective To investigate the chemical constituents from Guanxinning Injection.Methods The chemical constituents were repeatedly isolated by column chromatographic techniques including silica gel,ODS,Sephadex LH-20,and macroporous resin,and were purified by preparation HPLC chromatography and recrystallization,and their structures were identified by physicochemical properties and spectroscopic data.Results Nineteen compounds were isolated and identified as protocatechuic aldehyde(1),vanillin(2),ferulic acid(3),2-furoic acid(4),senkyunolide I(5),caffeic acid(6),salvianolic acid A(7),isosalvianolic acid A(8),salvianolic acid B(9),isosalvianolic acid C(10),rosmarinic acid(11),1,3-dicaffeoylquinic acid(12),senkyunolide H(13),4-hydroxybenzoic acid(14),m-hydroxybenzoic acid(15),o-hydroxybenzoic acid(16),4-hydroxycinnamic acid(17),methyl rosmarinate(18),and salvianolic acid N methyl ester(19).Conclusion Nineteen compounds are isolated from the Guanxinning Injection for the first time,and all HPLC analyses and literature data show that compounds 2,3,5,13—16 are originated from Ligusticum chuanxiong,compounds 7—11,and 18—19 from Salvia miltiorrhiza,and compounds 1,4,6,12,and 17 from L.chuanxiong and S.miltiorrhiza.
【Fund】: 教育部新世纪优秀人才支持计划(NCET-12-0977)
【CateGory Index】: R286.0
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