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《Chinese Traditional and Herbal Drugs》 2017-23
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Preparation of solid dispersion of Polygonum cuspidatum extract by hot melt extrusion

XU Yan;ZHANG Xin-yi;Di Liu-qing;FAN Wen-ling;Pharmacy School,Nanjing University of Chinese Medicine;Jiangsu Engineering Research Center for Efficient Delivery System of Traditional Chinese Medicine;Nanjing University of Chinese Medicine Collaborative Innovation Center of Chinese Medicinal Resources Industrialization of Jiangsu Province;  
Objective To prepare solid dispersions(SD) of Polygonum cuspidatum extract(PCE) with the intention of improving the dissolution rate of its active ingredients in vitro and exploring the applicability of hot melt extrusion in SD of traditional Chinese medicine extract.Methods The SD of PCE were prepared via hot melt extrusion based on Eudragit EPO.The cumulative dissolution of resveratrol and emodin in the extract of PCE was used as an evaluation index,and the single factor experiment was optimized.Then physicochemical properties of the SD prepared by optimized process were investigated by differential scanning calorimetry(DSC),powder X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR),and scanning electron microscope(SEM).Results The optimized process was 120 r/min for screw speed,160 ℃ for barrel temperature and liquid nitrogen cooling.Under the optimized conditions,the dissolution rate of resveratrol and emodin in the extract was significantly improved,and the drug was present in the amorphous state in the carrier.Conclusion Hot melt extrusion can prepare SD of PCE to improve the dissolution rate of resveratrol and emodin,which provided experimental reference and data support for the study of preparation of SD of traditional Chinese medicine by hot melt extrusion.
【Fund】: 国家自然科学基金资助项目(30801552 81274095);; 江苏省中药资源产业化过程协同创新中心第三批立项资助重点项目(012092002006-10);; 第55批博士后课题(021062001001)
【CateGory Index】: R283.6
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