Primary bone anaplastic large cell lymphoma:a clinicopathological analysis
ZHOU Zhi-yi, CHENG Jing, SHI Qun-li, et al.(Department of Pathology, Nanjing University Medical College/Nanjing General Hospital of Nanjing Command, Nanjing 210002, China)
Objective To investigate the clinicopathologic characteristics, differential diagnosis and prognosis of primary bone anaplastic large cell lymphoma. Methods We examined the clinicopathologic and immunohistochemical features in 4 cases of primary boned anaplastic large cell lymphoma, followed up for 7 to 45 months and reviewed the related literatures. Results Primary boned anaplastic large cell lymphoma mainly occured in the male patients with young or middle age. Tumor cells infiltrated bone, exhibited high pleomorphism and a large amount of mitotic figures. Immunohistochemical studies found that all tumors reacted positively with CD30 and EMA, and the cases frequently expressed ALK-1 and granzyme B. Among 4 follow-up patients, 2 cases died within 7 months and 11 months of diagnosis respectively. Conclusions Primary bone anaplastic large cell lymphoma is extremely uncommon. The definite diagnosis should be based on the histopathological and immunohistochemical features to exclude other tumors. The prognosis is possibly heterogeneous.
【CateGory Index】： R738