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《Chinese Journal of Endemiology》 1985-01
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EFFECT OF SELENIUM METHIONINE AND VITAMIN C ON cAMP cGMP LEVELS IN THE PLASMA HEART AND LIVER TISSUES Of RATS FED BY THE GRAIN CULTIVATED IN KESHAN DISEASE ENDEMIC AREA

Fu Guisheng  
Keshan disease is a local heartdisease that is not known cause.Itis reported that selenium can prev ent it,sufficient vitamin C cancure it.Way can they do it? Afterrats are fed by Keshan disease areagrain,we use radioimmunoassay tomeasure cAMP cGMP levels in theirplasma,heart and liver tissues.Theresult is fround cAMP marked dec-rease;cGMP obvious increase incomparison with the group fed byXian grain.After they are given selenite,methionine,vitamin C respectively.The cAMP cGMP levels in theirplasma,heart and liver tissues all ret-urn to xian group normol levels.Inthe same time,we also measure gl-utathione peronidase activity theincrease dose not accord with cAMPcGMP change.It is deduced that se-lenium,methionine and vitamin Cplay a antioxidation role in differ-ent ways in the metabolism.Ther-eby,they protect bio-membranefrom peroxide damage,we believethat it is probably better to prev-ent andcure Keshan disease to usedifferent anti-oxidants.
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【References】
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【Citations】
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1 Chen Nianzu Zhu Shiying Zhang Tiesuo;Effect of Diet in Keshan Disease on Hepatic Glycogen and Ribonucleic Acid(RNA)in Pigs[J];Chinese Journal of Endemiology;1982-04
【Co-citations】
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1 Ye Xueqing , Gao Xiaojian, Guo Yao, Zhang Huayan and Chen XuefuDepartment of Gynecology and Department of Pharmacy, Xijing Hospital 403-1 Labratory;Experimental and Clinical Observations on the Effects of Jiarong Tablet in the Treatment of Hypofunctional Diseases of Gonad Axis[J];Journal of The Fourth Military Medical University;1989-02
2 TAO Jing-Yi, RUAN YU-Ping, MEI QI-Bing, LIU Shen, TIAN Qiao-Lian, CHEN Yue-Zu* ZHANG Hui-Di* and DUAN Zhi-Xing* (Department of Pharmacology, 4 th Military Medical College, Xian; *Department of Organic Analysis. Lanzhou University);STUDIES ON THE ANTIASTHMATIC ACTION OF LIGUSTILIDE OF DANG-GUI, ANGELICA SINENSIS (OLIV.) DIELS[J];Acta Pharmaceutica Sinica;1984-08
3 Yi Hua(403 Research Department, the Fourth Military Medical college, Xian);EFFECTS OF VITAMIN E ON URINARY CYCLIC NUCLEOTIDE EXCRETION OF COLD-EXPOSED RATS[J];Acta Nutrimenta Sinica;1985-04
4 Che Naizeng, et al. Xijing Hospital, The Fourth Army Medical University, Xi'an;ANALYSIS OF cAMP LEVEL IN PSORIASIS LESION AND NORMAL HUMAN SKIN[J];The Chinese Journal of Dermatovenereology;1988-01
5 Gao Xiao-Jian, Wang Rong-Guang, et al Department of Obstetrics and Gynaecology, First Affiliated Hospital, Fourth Military Medical University, Xian;A preliminary study of leucine-enkephalin and its effect in the uterus[J];Chinese Journal of Pathophysiology;1990-02
6 Chen Nianzu Yang Jianguo Qi Songren;Some Histochemical Changes of Lipid Metabolism in Liver Tissues of Rats Fed on the Diet from Keshan Disease Affected Area[J];Chinese Journal of Endemiology;1984-01
7 Zhao Jian-Bin et alDepartment of Traditional Chinese Medicine, Xijing Hospital, The Fourth Military Medical College, Xi-an;Effects of Psoralen and 8-Methoxypsoralen on the Levels of Cyclic Nucleotide in Sarcoma-180 Cells in vitro[J];Chinese Journal of Clinical Oncology;1991-01
【Co-references】
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1 Zhou Bao-chu, et al (Institute of Keshan Disease, Harbin Medical University);The Effect of Dietary Se and Mn on the Glutathione Peroxidase Activity, Se and Mn Levels in Blood and Tissues of Rats[J];Endemic Disease Bulletin;1991-01
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5 Xiang Ruihua Jia Xian(Department of Biochemistry);EFFECTS OF SELENIUM AND METHIONINE ON LYSOSOME MEMBRANE IN RATS FED SEDEFICIENT GRAIN FROM KESHAN DISEASE ENDEMIC AREA[J];Journal of Xi'an Jiaotong University (Medical Sciences);1987-03
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7 Yuan Chunhai;CONTENTS OF ESSENTIAL AMINO ACIDS AND TRACE ELEMENT Mn,Se IN GRAINS FROM SEVERE KESHAN DISEASE ENDEMIC AREAS AND THEIR ROLES IN ETIOLOGY[J];Chinese Journal of Endemiology;1988-05
8 Wang Fan;Recent advances of study on etiology of Keshan disease[J];Chinese Journal of Endemiology;1989-01
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10 Li Fang Sheng;Progress of studies on the pathogenesis of Keshan disease(endemic mitochondrial cardiomyopathy)—nutritional oxidative stress disorder[J];Chinese Journal of Endemiology;1990-04
【Secondary References】
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1 ZHENG Bai hong, YU Ming tao, ZHENG Bai bo △, JIANG Gui ying  (Department of Pediatrics, Second Hospital, Jilin University, Changchun 130041, China);Effect of selenium on lipid peroxidation damage in children with acute viral myocarditis[J];Journal of Jilin University of (Medicine Edition);2004-03
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3 Li Qingya;Zhao Jinpei;Yang Zhikui;Zhou Zhenying(Institute of Militarv Medicine, Beijing Military Region, Shijiazhuang,050081);THEEFFECT OF SHANCAOGEN COMPOUND ON INCREASING CEREBRAL BLOOD SUPPLY AND RESISTING HYPOXIA AND FATIGUE IN MICE[J];JOURNAL OF PREVENTIVE MEDICINE OF CHINESE PEOPLE'S LIBERATION ARMY;1996-02
4 Yan Liping,Wang Zhanggui;Research advance in interaction of selenium and methionine[J];China Feed;2011-15
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【Secondary Citations】
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1 CHANG TSO-KAN Department of Anatomy, Chinese Union Medical College, Peking;MODIFICATON OF METHYL GREEN-PYRONIN TECHNIQUE FOR DIFFERENTIAL STAIN OF NUCLEIC ACID[J];Acta Anatomica Sinica;1954-02
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