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《Chinese Journal of Endemiology》 1990-01
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Changes of lipid peroxidation and antioxidation in serum and erythro cites in the rats with chronic fluorosis

Guan Zhizhong  
72 wistar rats were randomly divided into the test groups,drinking watercontained 10 ppm and 30 ppm fluoride respectively,and the control group drink-ing low-fluoride water.The rats were killed at the fifth and eighth month afterthe experiment respectively.The results showed that the level of lipid peroxidat-ion in serum and erythrocites was higher,but glutathione peroxidase activityand reduced glutathione content were declined in the rats drinking watercontained 10 ppm fluoride at the eighth month after the experiment and in therats drinking water contained 30 ppm fluoride at the fifth and eighth month ascompared with the control.Superoxide dismutase activity was not any changes.The higher level of lipid Peroxidation may be an important mediating factorfor the pathogenesis of chronic fluorosis.
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