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《Chinese Journal of Endemiology》 1991-03
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The influence of high-fluorine on DNA stability in the human body

Li Jie,et al  
With peripheral blood lymphocyte culture,a study of SCE and micronuclei testwas done in 24 patients with fluorosis and same number of normal people as con-trol.The results obtained showed that in the patient group the mean value ofSCE per cell and the frequency of micronuclei were 10.24±1.67 and 1.42‰,respe-ctively,while in the control only 7.62±0.80 and 0.33‰,respectively,were foundAnd both of the two respective parameters,statistically,were in significant dif-ference.These findings suggested that excess fluorine would cause increases of SCEfrequency and micronuclear number in lymphocyte and make DNA damaged.
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