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《CHINESE JOURANL OF CNDEMIOLOGY》 1999-05
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Histom orphom etric analysis of bone and effects of selenium on rats w ith chronic fluorosis

Y A N G Xiao xia, Y E Ping, B I A N Jian chao,et al( Shandong Institute of Prevention and Treatm ent of End em ic Disease, Jinan 250014, China)[  
Objective To observe the effects of selenium on pathologicalchangs of bone histo m orphom etry in rats w ith chronic fluorosis. M ethods 2 groups of W istar rats w ith chronic fluorosisw ere duplicated w ith 1.58、2.63m m ol/ L fluorine ( F Na F) in drinking w ater and 2.0m g/kg selenium( Se Na2 Se O3) w as supplem ented in groups of rats w ith fluorsis. The contents of Fin urine,serum andbones w ere exam ined and the param eters of bone histom orphom etry w ere perferm ed in 8、14 m onths. Results There w as an increase of urine,serum and bone F,the param eter of bone m orphology T B V Sos increased, Sr decreased and the param eters of bone dynam ics D D L. M I A R ascended, M O S W and M L T prolonged in rats w ith chronic fluorosis. The increase ofurine F,the decrease of serum and bone F and the recovery of the param eters of bone histom orphom etry w ere observed in rats w ith Se and Fsupplem ent. Conclusions There w as a balance disorder of bone m odeling,bone proliferation w asstim ulated by F and obstruction of bone m ineralization occured. After supplem ent of Se,the param e ters of bone histom orphom etry w ere affected,bone volum e low ered and obstruction of bone m ineral ization w as restrained in rats w ith fluorosis.[
【Fund】: 山东省卫生厅资助项目
【CateGory Index】: R599.9
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