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The effects of lipid peroxidation in mouse brain caused by chronical fluorosis,arsenism and fluoride-arsenic poisoning,respectively

LUI Qi-zhan, HUANG Hou-jin, DONG Guo-bin, ZHOU Yuan-zhong, WANG Jian-hua, HU Bin-li, LI Hong, ZHAO Man-ping (Department of Preventive Medicine, Zunyi Medical College, Zunyi 563003, China)  
Objective To study the levels, similarities and differences in the injury effects of lipid peroxidation in mouse brains caused by chronical fluorosis, arsenism and fluoride-arsenic poisoning,respectively.Methods One hundred and twenty mice were randomly divided into four groups which were fed with four different diets supplemented nothing, fluoride, arsenic and fluoride-arsenic,respectively for 6 and 12 months. The contents of brain LPO, GSH and the activities of brain SOD, GSH-Px,SDHase and G-6-Pase were determined.Results In the three poisoning groups: the LPO contents in brain were significally increased.The GSH contents and the activities of SOD and GSH-Px in brain were markedly decreased.The decreases of brain SDHase and G-6-Pase activities were significant. However, the effects of the three diffienert poisonings on these indices were different.Conclusions In mice,the effects of lipid peroxidation injuries in brain are induced by chronical fluorosis, arsenism and fluoride-arsenic poisoning, respectively; subcellular location of the brain injuries may be mitochondria and microsomes; to some extent,fluoride and arsenic can influence each other these effects.
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