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Influence of fluoride on the contents of testosterone and cholesterol

Zhao Zhongliang; Wu Nanping; Gao Wenhua; et al(Depart. of Preventive Medicine,Ningxia Medical College 750004)  
Wistar male rats were randomly divided into three groups drinking water contained 0.6mg/L(control group), 100mg/L, 200mg/L fluoride respectively. The rats were killed at the second,fourth and sixth week after experiment respectively. The levels of serum testosterone,testis cholesterol and hepatic cholesterol were inspected. The results showed that the level of serum testosterone had the tendency of decrease as the period of time was prolonged in the rats drinking water contained 100mg/L, 200mg/L fluoride. The level of cholesterol in testis did not changed significantly,but in liver it was significantly declined at the fourth and sixth week as compared with the control group. The results suggest that fluoride may have the harmful effect on the reproductive system.
【CateGory Index】: R599.902
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