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An experimental study on effects of high fluoride and supplied selenium on thyroid in rats

Lu Chuanhua,Guo Xiaowei,Bian Jianchao,et alShandong institute for endemic disease control and research,Jinan 250014  
 The metabolism of urinary fluoride,thyroid tissue structure and thyroid hormones in sixty rats drunk high fluoride water with 30 or 50mg Fper liter and fed with the selenium (Se) 2.0mg per kilogram were observed to study the effects of high fluoride and supplied Se on thyroid.Results indicated that levels of urinary fluoride raised along with the prolongation of months after drinking high F and excretive contents increased at early stage (4 months) after supplying Se.Thyroid follicular epithelial cells were proliferated actively,and at the same time,the levels of serum free thyroid hormones were higher than those of the control group at early stage.But at late stage (8 months) thyroid follicular epithelial cells appeared retrograde degenerative changes and levels of serum FT3,T4 were lower than those of the control group.There were some relationships between Se and thyroid hormones.It suggested that fluoride could excite thyroid gland,making thyroid functions in state of high compensation at early stage,but could inhibit thyroid gland causing hypothyroidism at late stage.The changes of fluoride and thyroid tissues or thyroid functions were in close relationship with months after drinding fluoride water
【CateGory Index】: R322.51,R599.9
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