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《China Modern Doctor》 2013-10
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The study on effects of radix ranunculus ternate saponins on the activity of human hepatocarcinoma cell line HepG2

CHEN Xuan TONG Yeling YANG Feng DAI Guanhai REN Zeming WANG Bobo Institute of Basic Medicine,Zhejiang Academy of TCM,Hangzhou 310007,China  
Objective To evaluate the effects of radix ranunculus ternate saponins on the activity of human hepatocar cinoma cell line HepG2.Methods The saponins were extracted from radix ranunculus ternate using systematic solvent extraction method.Human hepatocarcinoma cell line HepG2 were treated with the extracts.Cell proliferation was eval uated by 3H-TdR incorporation method and colony formation assay.Results The radix ranunculus ternate saponins could significantly inhibit cell proliferation and colony formation of HepG2 dose-dependently.Conclusion Radix ranunculus ternate saponins could inhibit cell proliferation and colony formation of HepG2 effectively.
【Fund】: 浙江省中医药管理局资助项目(2011ZB010)
【CateGory Index】: R735.7
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