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《China Modern Doctor》 2018-02
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Clinical effect observation on application of sevoflurane general anesthesia in the treatment of sepsis patients

HU Jingchun;QIAN Lijun;LEI Lipei;WU Wei;ZHENG Wangfu;WANG Wu;Department of Anesthesiology,Lishui Central Hospital in Zhejiang Province;Department of Pediatrics,Lishui Central Hospital in Zhejiang Province;  
Objective To investigate the clinical effect of sevoflurane general anesthesia in the treatment of sepsis patients. Methods 74 patients with sepsis who underwent surgical treatment in the Department of Surgery in our hospital from March 2016 to February 2017 were divided into two groups, according to the different ways of maintaining anesthesia. All patients were given general anesthesia. The control group was maintained with propofol during operation. The observation group was maintained with sevoflurane. The changes in vital signs, changes in respiratory function indicators, adverse reactions and surgical outcome were compared between the two groups. Results The mean arterial pressure and heart rate after anesthesia in the observation group were controlled more smoothly than those in the control group,and the difference was statistically significant(P 0.05). There was no significant difference in the oxygen saturation be tween the two groups(P0.05). The levels of oxygenation index(OI), partial pressure of carbon dioxide(PaCO_2), airway pressure(Paw), blood lactic acid and pulmonary dynamic compliance in the observation group were significantly different from those in control group be fore surgery, at 30 min during the operation, at the end of surgery and at 24 h after surgery(P0.05). The incidences of adverse reactions such as nausea and vomiting, headache, allergies and chills were significantly lower than those of the control group, the differece was statistically significant(P0.05). There was no significant difference in the incidence of endotracheal intubation removal, postoperative ARDS incidence and postoperative24 h mortality in the operating room(P0.05). Conclusion The sevoflurane applied in sepsis patients has good effect,which can maintain the vital signs stable during operation, and has less effect on the respiratory function. It is conducive to the surgical effect, and has a positive clinical significance.
【Fund】: 浙江省医药卫生科技计划项目(2016KYB337)
【CateGory Index】: R614
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