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《China Modern Doctor》 2018-03
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Effect of sevoflurane combined with sufentanil on the perioperative inflammatory factors in the patients undergoing lumbar spine internal fixation

LIU Xiaoguo;XIA Xingui;YANG Shizhong;CHEN Yanqin;Department of Anesthesiology, Zhejiang PAP Corps Jiaxing Hospital;  
Objective To investigate the effects of sevoflurane combined with sufentanil on the perioperative hemodynamics and inflammatory factors in the patients undergoing lumbar spine internal fixation. Methods A total of 80 patients undergoing selective surgery of lumbar spine internal fixation were randomly divided into the sevoflurane group(n=40): inhaled anesthesia with sevoflurane for maintenance, and the control group(n=40): propofol intravenous anesthesia for maintenance. Both groups were given intravenous injection of sufentanil to maintain intraoperative analgesia after induction of anesthesia. The hemodynamic parameters 5 min before induction of anesthesia(T_0), immediately after tracheal intubation(T_1), 1 min after skin incision(T_2), immediately before the removal of the tracheal tube were monitored and recorded. Peripheral venous blood at T_0, T_3, 8 h after operation(T_4), 24 h after operation(T_5) was drawn. The levels of C-reactive protein(CRP), tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) were measured by ELISA method.Results There was no significant difference in anesthesia induction time, operation time, intraoperative blood loss and hemodynamic indexes at each time point between the two groups. Compared with T0, CRP, IL-6 and TNF-α in the two groups began to increase at T_3, reached the highest at T_4(P0.05), and significantly increased at T_5(P0.05). The levels of CRP and IL-6 in sevoflurane group at T_3, T_4, T_5 time points were significantly lower than those in the control group(P0.05). At T_4 and T_5 time points, TNF-α was significantly lower than the control group(P0.05). Conclusion Compared with the propofol combined with sufentanil for anesthesia, sevoflurane combined with sufentanil for anesthesia has a favorable effect for lumbar spine internal fixation. The intraoperative hemodynamic index is stable, which can effectively inhibit the release of inflammatory cytokines, and is beneficial to patients' anesthesia and surgical safety.
【Fund】: 浙江省嘉兴市科技计划项目(2017BY18044)
【CateGory Index】: R614
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