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《Chinese Journal of Lung Diseases(Electronic Edition)》 2019-03
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Clinical analysis of local treatment of bronchial tuberculosis under bronchoscope

Fan Huiming;Wei Hailong;Luo Lincheng;Liu Wei;Department of Respiratory and Critical Care Medicine,Leshan People' s Hospital;  
Objective To explore the characteristics of bronchial tuberculosis under a bronchoscope and analyze the clinical effect of local treatment of bronchial tuberculosis under a fiberoptic bronchoscope.Methods The clinical data of 92 cases of bronchial tuberculosis admitted to the Department of Respiratory and Critical Care Medicine of Leshan People' s Hospital in Sichuan Province in China from January 2016 to December 2017 were retrospectively analyzed. The patients were divided into an observation group( n = 48) and a control group( n = 44) according to the random number table method. The patients in both groups were treated with the standardized 3 HRZE/9 HR anti-tuberculosis oral drug therapy and atomization inhalation therapy,and the patients in the observation group was treated with local drug injection under a fiberoptic bronchoscope on this basis. The sputum acid-fast bacilli negative conversion rate at 1,2,3 and 6 months of treatment and the clinical efficacy at 6 months of treatment were compared between the two groups. The adverse reactions during the treatment were recorded and a long-term follow-up was conducted. Results The sputum negative conversion rate in the observation group was significantly higher than that in the control group at 3 and 6 months of treatment( P0.05). The total effective rates were 85.42% in the observation group and 63.64% in the control group,with a statistically significant difference between the two groups( P 0. 05). There was no significant difference in the adverse reactions between the two groups( P 0. 05). In the observation group,48 cases of bronchial tuberculosis were treated with anti-tuberculosis and bronchoscopy for 12 months and were all clinically cured. The clinical cure rate of 44 cases of bronchial tuberculosis in the control group was 77. 27%. The difference of the long-term clinical cure rate between the two groups was statistically significant( P = 0.000).Conclusion Local treatment for the patients with bronchial tuberculosis under a fiberoptic bronchoscope combined with conventional anti-tuberculosis drugs can effectively promote the sputum negative transformation,improve the clinical efficacy and shorten the treatment period.
【CateGory Index】: R521.1
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