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《Chinese Journal of Antituberculosis》 2013-10
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Analysis of the sputum negative conversion rate and risk factors for primary pulmonary tuberculosis with tracheobronchial tuberculosis

KUANG Hao-bin;LIANG Min-qing;FANG Qiong;HE Qiao;CHENG Wu;KUANG Xiao-jia;LIAO Jin-liang;TAN Shou-yong;Guangzhou Chest Hospital,State Key Laboratory of Respiratory Diseases;  
Objective To explore the sputum negative conversion rate and risk factors of curative effect for pulmonary tuberculosis(PTB)with tracheobronchial tuberculosis(TBTB).Methods Two hundred and five primary PTB cases with TBTB were confirmed by bronchoscopy in Guangzhou Chest Hospital from Jul 2011 to Feb 2012,all of whom received chemotherapy of 2-3HRZE/9-10HR and different transbronchoscopic interventional therapy according to TBTB types.After more than 6 months' following-up,the sputum negative conversion rates after 2 months treatment and 6 months treatment were analyzed,and risk factors were also analyzed by backward logistic regression analysis.Results After the treatment of 2 months and 6 months,the sputum negative conversion rate were 59.0%(121/205)and 90.2%(185/205)respectively.Multiple-factor logistic regression analysis showed that age(OR=1.013,P=0.061,95%CI=0.992-1.035),lesion range(OR=2.012,P=0.022,95%CI=0.9484.273),number of cavity(OR=1.655,P=0.031,95%CI=1.116-2.453)and drug resistance(OR=1.298,P=0.047,95%CI=0.7962-2.117)were risk factors of sputum non-negative conversion after 2months' treatment.The drug resistance(OR=1.452,P=0.022,95%CI=0.818-2.575)and sputum positive after 2 months' treatment(OR=18 241.990,P=0.008,95%CI=0.000-6.4×108)were the risk factors of sputum positive after 6 months' treatment.Conclusion The sputum negative conversion rate is relatively low for PTB with TBTB after 2 months' treatment.It needs to intensify treatment and management and improve treatment compliance.The risk factors of sputum non-negative conversion after 2 months' treatment were age,lesion range,number of cavity and drug resistance,while those after 6 months' treatment were drug resistance and sputum positive after 2 months' treatment.
【Fund】: 广东省医学科研项目(A2011497);; 广州市卫生局科研项目(201102A213156)
【CateGory Index】: R521
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