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《Chinese Journal of Antituberculosis》 2020-01
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Study on resistance to rifampicin and isoniazid in 411cases of pulmonary tuberculosis in Longyan City,Fujian Province

ZHANG Man e;HUANG Wen-bin;LU Zhi-hua;ZHANG Hong-bin;Department of Molecular Biology Laboratory,the Second Hospital of Longyan,Fujian Province;  
Objective To retrospectively analyze the drug resistance to rifampicin and isoniazid in 411 cases of pulmonary tuberculosis(PTB)in Longyan City,Fujian Province,and provide a scientific basis for the prevention and treatment of tuberculosis in local areas. Methods From May 12,2016 to August 17,2019,411 PTB patients who admitted to the outpatient department and hospitalized in the Second Hospital of Longyan City,Fujian Province were collected,including 312 patients with initial treatment and 99 patients with retreatment.Resistance to rifampicin and isoniazid and the mutation sites of related resistance gene were detected in 411 clinical isolates of Mycobacterium tuberculosis using gene chip technology,and the results were compared between patients with initial treatment and retreatment.Data were collated and statistically analyzed using Excel 2003 and SPSS 20.0 software,respectively.Comparison of count data was performed using theχ~2 test.P0.05 was considered statistically significant. Results In 411 PTB patients,the mutation rate of rifampicin and isoniazid at any site of patients with initial treatment was significantly lower than that with retreatment(9.3%(29/312)vs 54.5%(54/99),χ~2=95.483,P0.05);and the multidrug-resistance rate of patients with initial treatment was obviously lower than that with retreatment(2.9%(9/312)vs 33.3%(33/99),χ~2=75.944,P0.05).The mutation rate of rifampicin and isoniazid at any site was 20.2%(83/411),among which,the mutation rate of rifampicin resistance gene(ropB)was 5.4%(22/411),including 20 cases with single-site mutations and 2 cases with double-site mutations,and the mutation frequency of 531(C→T)was the highest(40.9%(9/22));the mutation rate of isoniazid resistance genes(katGand inhA)was 4.6%(19/411),including 13 cases with katG mutation and 6 cases with inhA mutation,and the mutation frequency of 315(G→C)was the highest(63.2%(12/19));the multidrug-resistance rate was 10.2%(42/411),including 40 cases with double-site mutations,1 case with three-site mutation and 1 case with four-site mutation,and the mutation frequency of 531(C→T)315(G → C)was the highest(47.6%(20/42)).Conclusion The drug resistance of PTB patients in Longyan City is mainly multidrug-resistant.The resistance to two drugs in patients with retreatment is more serious than that in patients with initial treatment,indicates that the situation of prevention and treatment is grim.
【CateGory Index】: R521;R446.5
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【Citations】
Chinese Journal Full-text Database 7 Hits
1 CUI Xiao-li;YANG Han;WU Xia;ZHENG Dan;YOU Zhen-yu;DANG Li-yun;Xi'an Chest Hospital;;Analysis of drug susceptibility and drug resistance gene locus mutation in 958 tuberculosis patients[J];中国防痨杂志;2019-05
2 DU Yong-cheng;DAI Zhi-song;LIANG Qing-fu;LIN Yong-ming;HUANG Zhi-zhong;LI Wei-lin;CHEN Dan-sheng;ZHAO Yong;WEI Shu-zhen;LIN Jian;CHEN Dai-quan;CHEN Jiang-fen;ZHOU Yin-fa;LIU Zhen-ni;LIN Shu-fang;Division of Tuberculosis Control and Prevention,Fujian Center for Disease Control and Prevention;;Analysis on the results of tuberculosis epidemiological sampling survey in Fujian Province in 2014[J];中国防痨杂志;2016-09
3 YANG Ya-bing;BO Xiao-zhen;GAO Fei;Inner Mongolia Medical University;Foutrh Hospital of Inner Mongolia Autonomous Region;;Advances in Molecular Mechanism of Anti-drug-resistant Tuberculosis Drugs[J];内蒙古医学杂志;2015-02
4 LIN Shu-fang;LIANG Qing-fu;CHEN Qiu-yang;PANG Yu;WEI Shu-zhen;LIN Jian;ZHAO Yong;Fujian Center for Disease Control and Prevention;Teaching Base of Fujian Medical University;National Tuberculosis Reference Laboratory,National Center for ,TB Control and Prevention,Chinese Center for Disease Control and Prevention;;Mutations of drug-resistance genes related to INH in Mycobacterium tuberculosis isolates in Fujian Province,China[J];中国人兽共患病学报;2014-06
5 CHEN Qiu-yang,LIN Shu-fang,LIANG Qing-fu,WEI Shu-zhen,ZHAO Yong,LIN Jian,ZHENG Jin-feng.Department of tuberculosis control of Fujian Provincial Center for Disease Control and Prevention,Fuzhou 350001,China;Tuberculosis drug resistance surveillance report in Fujian province[J];中国防痨杂志;2013-07
6 LIANG Qing-fu,CHEN Qiu-yang,ZHAO Yong,et al.Department of Tuberculosis and Leprosy,Fujian Provincial Center for Disease Control and Prevention(Fuzhou 350001,China);Analysis of drug resistance surveillance of tuberculosis in Fujian province[J];中国公共卫生;2012-04
7 WEI Shu-zhen,SONG Ying,CHEN Qiu-yang,et al.(1.Fujian Provincial Center for Disease Control and Prevention,Fuzhou 350001,Fujian,P.R.China);Survey of 160 drug resistant pulmonary tuberculosis patients in Longyan City,Fujian[J];中国热带医学;2011-09
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 SHI Lian;REN Yi-jie;XI Ying;SHI Lei;GUO Chen;GUAN Jian;No.8 Tublerculosis Ward,Shenyang Chest Hospital;;Detection value analysis of three laboratory techniques for diagnosing tuberculosis and drug resistance in smear-positive patients[J];中国防痨杂志;2019-11
2 WANG Yan-fu;QI Zheng;YANG Wei;LIU Chang;LI Hong-hai;WANG Xin;Institute of Multidrug-resistant Control,Heilongjiang Province Center for Tuberculosis Control and Prevention;;Epidemiological characteristics of newly registered smear positive pulmonary tuberculosis in Heilongjiang province from 2008 to 2015[J];中国防痨杂志;2018-02
3 LI Gang;SUN Chang-jiang;Gou Yu-jie;Department of Tuberculosis,Heihe Center for Disease Control and Prevention of Heilongjiang Province;;Analysis of drug resistance in tuberculosis patients in Heihe city of Heilongjiang Province from 2015 to 2016[J];结核病与肺部健康杂志;2017-04
4 XU Lin;CHEN Lianyong;MA Li;YANG Huijuan;Yunnan Center for Disease Control and Prevention;;Drug Resistance Surveillance of Tuberculosis in Yunnan Province[J];预防医学情报杂志;2015-12
5 LIU Xiaomin;FAN Mingkuan;XIE Bing;WANG Xian;YUAN Xia;Xiangyang Hospital for Tuberculosis Control and Prevention;;Drug-resistant Status of Tuberculosis Patients in Xiangyang City,Hubei Province[J];预防医学情报杂志;2015-12
6 PAN Jie-ru;LIANG Qing-fu;YE Hai-mei;LIN Ping;Fuzhou Center for Disease Control and Prevention;;Analysis of drug resistance surveillance of tuberculosis in Fuzhou[J];中国卫生检验杂志;2015-19
7 WEI Shu-zhen;LIANG Qing-fu;LIN Shu-fang;ZHAO Yong;LIN Jian;LIN Yong-ming;CHEN Qiu-yang;Fujian provincial center for disease control and prevention;;Analysis on drug resistance of retreated pulmonary tuberculosis cases and risk factor associated with drug resistance in Fujian[J];现代预防医学;2015-16
8 WEI Shu-zhen;LIN Shu-fang;ZHAO Yong;LIN Jin;LIANG Qing-fu;LIN Yong-ming;Fujian Center for Disease Control and Prevention;;Evaluation on the performance of GenoType MTBDRplus assay for rapid diagnosis MDR Mycobacterium tuberculosis isolates in Fujian Province,China[J];中国人兽共患病学报;2015-08
9 WANG Zhong-dong;ZHANG Hua-qiang;XUE Bai;Qingdao Municipal Center of Disease Prevention and Control;;Prevalence and risk factors of multidrug-resistant tuberculosis in Qingdao region[J];中国公共卫生;2015-09
10 Zhang Liyue;Hu Yi;Wu Linlin;Jiang Weili;Xu Biao;Department of Epidemiology,School of Public Health,Fudan University;;The impact of isoniazid resistant Mycobacterium tuberculosis on the epidemic of multi-drug resistant tuberculosis[J];中华传染病杂志;2015-03
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 SHAN Yong-mei;WANG Wei-bing;WANG Jian-mei;Department of Chronic Infectious Diseases,Guanyun County Center for Disease Control and Prevention,Jiangsu;;The study of clinical application value of DNA microarray chip in detection of drug-resistant Mycobacterium tuberculosis[J];中国防痨杂志;2018-10
2 YANG Xiu-jun;ZHANG Wei-yu;ZHANG Li-fu;LI Ke-wei;Department of Microbiology Testing,Jilin Provincial Center for Disease Control and Prevention;;Mutation characteristics of the KatG gene of multidrug-resistant Mycobacterium tuberculosis isolates from Jilin province[J];中国防痨杂志;2017-08
3 TANG Nan;XU Lin;Faculty of Public Health in Kunming Medical University;;Comparison of the patients with delayed treatment among smear positive TB patients in Yunnan Province between 2005 and 2013[J];公共卫生与预防医学;2015-02
4 Liu Yaqin;Yang Zhenbin;Feng Dongxia;Wang Haiying;Department of Clinical Laboratory,Liaocheng Municipal Infectious Disease Hospital;;Research on DNA microarray chip method for detecting drug resistance of Mycobacterium tuberculosis[J];国际检验医学杂志;2014-14
5 HAO bao-lin;XING jin;LI Hui;Henan Center for Disease Control and Prevention;;Evaluation of a Biochip system for determining mutations associated with Mycobacterium tuberculosis multidrug resistance from clinic sputum sample[J];医药论坛杂志;2014-07
6 YANG Jin-ming;Jie'ensi·SIMAHULE;TAI Xin-rong;LI Yue-hua;ZHAO Zhen;Center for Disease Control and Prevention,Xinjiang Uygur Autonomous Region;;Analysis of tuberculosis epidemiological survey conducted in 2010—2011 in Xinjiang Uygur autonomous region[J];中国防痨杂志;2013-12
7 CHEN Qiu-yang,LIN Shu-fang,LIANG Qing-fu,WEI Shu-zhen,ZHAO Yong,LIN Jian,ZHENG Jin-feng.Department of tuberculosis control of Fujian Provincial Center for Disease Control and Prevention,Fuzhou 350001,China;Tuberculosis drug resistance surveillance report in Fujian province[J];中国防痨杂志;2013-07
8 CAI Jie1,LIU Xiao-xiang2,LI Zhao-dong3,WU Sen-lin2*(1.The Drug and Equipment Procurement Center of Zhejiang Province,Hangzhou 310004,China;2.Zhejiang Medical College,Hangzhou 310053,China;3.Department of Laboratory Medicine,Hangzhou Red Cross Hospital,Hangzhou 311201,China);Study on characteristics of katG,inhA and ahpC gene mutations in isoniazid resistant isolates of Mycobacterium tuberculosis[J];中国卫生检验杂志;2013-06
9 LIN Shu-fang,CHEN Qiu-yang,ZHENG Jin-feng,WEI Shu-zhen,DAI Zhi-song,LIN Yong-ming.Tuberculosis Prevention and Control Division in Fujian Provincial Center for Disease Control and Prevention,Fuzhou 350001,China;The evaluation of implementation effect of tuberculosis control program in Fujian province during 2001—2010[J];中国防痨杂志;2013-01
10 Technical Guidance Group of the Fifth National TB Epi-demiological Survey;The Office of the Fifth National TB Epidemiological Survey;The fifth national tuberculosis epidemiological survey in 2010[J];中国防痨杂志;2012-08
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