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《Chinese Journal of Antituberculosis》 2020-03
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Analysis of influencing factors of medication adherence among 120 newly diagnosed patients with multi-drug resistant pulmonary tuberculosis

YOU Yuan-yuan;ZHANG Guo-long;CHEN Yu;Department of Medical Affairs,Zhengzhou Sixth People's Hospital,Henan Infectious Diseases Hospital;  
Objective To analyze the influencing factors of medication adherence among patients with multidrug-resistant pulmonary tuberculosis(MDR-PTB) and to provide a basis for exploring and formulating diagnosis and treatment,management policies and measures for patients with MDR-PTB.Methods The cluster sampling method was used to collect the medical records and follow-up records of 120 newly diagnosed MDR-PTB patients who were diagnosed and treated and completed 24 months of follow-up at Henan Infectious Diseases Hospital during October 2015 to March 2017.A questionnaire survey on core knowledge of tuberculosis prevention was conducted by trained questionnaire surveyors to 120 newly diagnosed MDR-PTB patients,the valid withdrawal of the questionnaire was 120 with the withdrawal rate of 100.00%.The treatment compliance and its influencing factors were analyzed by unconditional dichotomous logistic regression analysis of univariate and multivariate.Results Among the 120 cases of newly diagnosed MDR-PTB,85 cases had good medication adherence and 35 cases had medication adherence.Multivariate regression analysis showed that:poor family economic status(Wald χ~2=5.483,P=0.019,OR=6.27,95%CI=2.51-13.92),adverse drug reactions(Wald χ~2=7.038,P=0.008,OR=4.73,95%CI=1.95-10.17),poor awareness of core knowledge on tuberculosis prevention(Wald χ~2=4.621,P=0.032,OR=2.07,95 % CI=1.03-5.65) and self-medication(Wald χ~2=5.925,P=0.010,OR=2.45,95% CI=1.92-7.01) were the main risk factors for treatment compliance.Conclusion Poor family economic status,adverse drug reactions,self-medication and poor awareness of core knowledge on tuberculosis prevention were the main risk factors for medication adherence,which can be used for reference in exploring and formulating MDR-PTB patients diagnosis and treatment,management policies and measures.
【Fund】: 河南省科技攻关计划(1821023310568)
【CateGory Index】: R521
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