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High rate of recanalization after unokinase infusion when continuously monitored with 2-MHz transcranial doppler monitoring

LIU Wei-song ZHANG Li-ming ZHU Shao-fen (Department of Neurology,The First Medical College,Harbin Medical University,Harbin 150001,China)  
Objective To determine whether ultrasonagraphy can safely enhance the thrombolytic activity of unokinase.Methods 26 patients were randomly assigned to receive continuous ultrasonography(the target group) or placebo(the control group).Residual flow signals were obtained from the clot location identified by TCD.Na- tional Institutes of Health Stroke Scale(NIHSS)and Barthel index were obtained before and after unokinase infu- sion.Results The percentage of recanalization in the target group was 76.9%,significantly higher than that in the control group(30.8%).NIHSS and Barthel index were significantly different after unokinase infusion between two groups.Conclusion TCD combined with unokinase is more effective than unokinase alone for acute cerebral in- farctions.
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